ArticleBMC chemistry2026
Chitosan-coated gold nanostars with photothermal activity for enhanced disinfection efficacy of sodium hypochlorite in antibacterial-based root canal therapy.
Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Enterococcus faecalis can persist in root canal isthmuses and accessory canals despite conventional irrigation with sodium hypochlorite (NaOCl). Although high concentrations of NaOCl are effective, they pose safety risks. Therefore, strategies to enhance the efficacy of low-concentration NaOCl are clinically desirable. This study aimed to evaluate whether coating gold nanostars (AuNS) with chitosan (CS) to form a nanohybrid (AuNS-CS) can enhance the antibacterial efficacy of low-concentration NaOCl under low-power laser irradiation. The synthesis and comprehensive analysis of AuNS-CS nanohybrids were completed. Root canal models inoculated with E. faecalis were prepared. The antibacterial and antibiofilm capabilities of NaOCl (0.1-2.5%) alone or in combination with AuNS-CS and 810 nm diode laser irradiation (500 mW, 1 min), were evaluated using a colony-forming unit (CFU)·mL
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