ArticleLipids in health and disease2026
Plasma fatty acid composition modifies the cardiovascular risk of long-term PM
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to investigate whether plasma fatty acid composition is associated with incident atherosclerotic cardiovascular disease (ASCVD) and whether it modifies the cardiovascular risk associated with long-term exposure to fine particulate matter (PM
methodsThis prospective cohort study included 428,048 UK Biobank participants free of ASCVD at baseline. Plasma fatty acids were quantified using
resultsDuring a median follow-up of 12.5 years, 45,880 incident ASCVD events were documented. Higher absolute fatty acid concentrations were positively associated with ASCVD risk, possibly reflecting underlying metabolic disturbances. In contrast, relative compositional indices, particularly the polyunsaturated-to-monounsaturated fatty acid (PUFA/MUFA) ratio and docosahexaenoic acid percentage (DHA%), were inversely associated with ASCVD risk. Compared with the lowest quartile, the highest quartile of the PUFA/MUFA ratio was associated with a 25% lower risk of ASCVD (hazard ratio [HR] = 0.75, 95% confidence interval [CI]: 0.73-0.77). A higher DHA% showed a similar inverse association. In joint analyses, significant additive interactions were observed between high PM
conclusionsA more favorable plasma fatty acid composition, characterized by a higher PUFA/MUFA ratio and higher DHA proportion, was associated with a lower risk of incident ASCVD and appeared to attenuate the excess cardiovascular risk associated with long-term PM
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