ArticleBMC bioinformatics2026
On the genetic origins of phenotypes in genome-wide association studies: the SAFE-h
Article in BMC bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundThis study highlights biologically meaningless negative contributions to heritability estimates and introduces SAFE-h
resultsBy examining 74 phenotypes across eight species, SAFE-h
conclusionsSNPs with potentially negative contributions to the heritability estimate should be excluded from the model. The widespread assumption that SNP-specific non-additive allelic effects are negligible does not rest on any inherent genetic or biological principles. The advantage of SAFE-h
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