ArticleRenal failure2026
Appraising the causal relationship between kidney function and hearing performance: a two-sample Mendelian randomization study.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epidemiological studies have reported an association between chronic kidney disease and hearing impairment, but the causal relationship remains uncertain. We conducted a bidirectional two-sample Mendelian randomization study to examine whether genetically predicted kidney function traits causally influence speech reception threshold, an objective measure of auditory performance. Genetic instruments for estimated glomerular filtration rate, chronic kidney disease, and blood urea nitrogen were obtained from large-scale genome-wide association studies conducted by the CKDGen Consortium, and summary statistics for speech reception threshold in the left and right ears were derived from the UK Biobank. The inverse variance weighted method was used as the primary analytical approach, complemented by MR-Egger, weighted median, and mode-based estimators. No robust causal associations were identified between genetically predicted kidney function traits and SRT in either ear. IVW estimates for BUN, CKD, and eGFR were non-significant (all
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