ArticlePediatric research2026
Post-neonatal epilepsy in newborns with neurologic conditions: a retrospective cohort study from a tertiary center.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the incidence and risk factors of epilepsy by ≥3 years of age in newborns presenting with a neurologic complaint.
methodsThis is a retrospective cohort study of all newborns admitted to the NICU at Children's National Hospital between 2004 and 2011 with a neurologic condition. Newborns were included if they had post-NICU follow-up for at least three years of age. Cox regression was used for analysis.
resultsA total of 344 newborns met study criteria. The incidence of epilepsy was 25%. The overall rate of developing epilepsy was 44 per 1000 person-years with a median age at onset of 1.85 years. Factors associated with an increased rate of epilepsy included neonatal seizures, hydrocephalus, grade 4 intraventricular hemorrhage, an abnormal EEG, a severe EEG background, the absence of state changes, and the presence of status epilepticus. Infants with a moderate EEG background severity and status epilepticus had the greatest rate of developing epilepsy (HR 10.06, 95% CI 2.66-37.98, p = 0.001). Patients with neonatal seizures were more likely to develop drug-resistant epilepsy (OR 3.41, 95% CI 1.19 to 9.76, p = 0.022).
conclusionRegular surveillance of epilepsy in high-risk newborns may aid in early diagnosis and treatment initiation. IMPACT: Epilepsy outcomes in neonates with neurologic conditions, e.g. acute brain injury, hydrocephalus, periventricular leukomalacia, or brain malformations, independent of presenting with neonatal seizures, are largely unknown This study addresses gaps in predicting post-neonatal epilepsy (PNE) by integrating demographic factors, neurologic diagnoses, neonatal seizure status, and EEG ictal/interictal features One in four newborns with a neurologic brain condition develops PNE regardless of presenting with seizures. EEG background abnormalities show the strongest association with PNE, while neonatal seizures increase the risk of drug-resistant epilepsy. These findings support improved risk counseling and closer surveillance, particularly during the first year of life.
Identifiers
42135561What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.