Evidence map›Paper›PMID 42135532›Full record

Trial reportNature medicine2026

Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial.

Raimon Sanmarti, Carolina Pérez-García, Francisco J de-Toro, Georgina Salvador, Alejandro Escudero-Contreras, Andrea Cuervo, Eduard Graell, Delia Reina, Eduardo Kanterewicz, Hèctor Corominas and 29 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Palindromic Rheumatism: Revisiting the Approach to an Enigmatic Condition.International journal of rheumatic diseases · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Raimon SanmartiRheumatology, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. sanmarti@clinic.cat.ORCID http://orcid.org/0000-0002-8864-3806
Carolina Pérez-GarcíaRheumatology, Hospital del Mar, Barcelona, Spain.
Francisco J de-ToroRheumatology, Complexo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidad de A Coruña (UDC), A Coruña, Spain.
Georgina SalvadorRheumatology, Hospital Universitari Mútua Terrassa, Terrassa, Spain.
Alejandro Escudero-ContrerasRheumatology, Reina Sofía University Hospital, IMIBIC, UCO, Córdoba, Spain.
Andrea CuervoRheumatology, Hospital General de Granollers, Granollers, Spain.
Eduard GraellRheumatology, Parc Taulí Hospital Universitari, I3PT, Universitat Autonoma de Barcelona, Sabadell, Spain.
Delia ReinaRheumatology, Complex Hospitalari Universitari Moises Broggi, Sant Joan Despí, Spain.
Eduardo KanterewiczRheumatology, Hospital Universitari de Vic, Vic, Spain.
Hèctor CorominasRheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Irati Urionaguena-OnaindiaRheumatology, Hospital Universitario Galdakao-Usansolo, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-5673-6557
Maria López-LasantaRheumatology, Hospital Vall d´Hebron, Barcelona, Spain.
Alejandro OlivéRheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Miquel Sala-GómezRheumatology, Hospital de Figueres, Figueres, Spain.
Beatriz Frade-SosaRheumatology, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.ORCID http://orcid.org/0000-0002-5867-8434
Rosa M Morlà-NovellRheumatology, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Luciano PolinoRheumatology, Hospital del Mar, Barcelona, Spain.
Juan Antonio Meraz-OstizRheumatology, Hospital del Mar, Barcelona, Spain.
Natividad OreiroRheumatology, Complexo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidad de A Coruña (UDC), A Coruña, Spain.
Francisco J BlancoRheumatology, Complexo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidad de A Coruña (UDC), A Coruña, Spain.
Inma Pérez-NadalesRheumatology, Hospital Universitari Mútua Terrassa, Terrassa, Spain.
Rafaela Ortega-CastroRheumatology, Reina Sofía University Hospital, IMIBIC, UCO, Córdoba, Spain.
Noemi Busquets-PérezRheumatology, Hospital General de Granollers, Granollers, Spain.
Antonio Domingo Gómez-CentenoRheumatology, Parc Taulí Hospital Universitari, I3PT, Universitat Autonoma de Barcelona, Sabadell, Spain.
Oscar CamachoRheumatology, Complex Hospitalari Universitari Moises Broggi, Sant Joan Despí, Spain.
José R Rodríguez-CrosRheumatology, Hospital Universitari de Vic, Vic, Spain.
Ana Milena Millan-ArciniegasRheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
José Francisco García-LlorenteRheumatology, Hospital Universitario Galdakao-Usansolo, Bizkaia, Spain.
Helena BorrellRheumatology, Hospital Vall d´Hebron, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9161-3886
Águeda Prior-EspañolRheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Sonia Castell-QuiñonesRheumatology, Hospital de Figueres, Figueres, Spain.
Ana CrucetaClinical Research Support Unit (CTU), Core facility. HCB-IDIBAPS. Hospital Clínic, Barcelona, Spain.
Eva BonfillClinical Research Support Unit (CTU), Core facility. HCB-IDIBAPS. Hospital Clínic, Barcelona, Spain.
Gemma Domenech-GómezMedical Statistics Core Facility, Fundació de Recerca Clínic Barcelona (FRCB)- Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Andreu Roca-FàbregasMedical Statistics Core Facility, Fundació de Recerca Clínic Barcelona (FRCB)- Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
José RíosDepartment of Clinical Pharmacology, Hospital Clinic and Medical Statistics Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), Barcelona, Spain. Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-0716-8784
Lola Tobalina-MaestreRheumatology, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
María José GómaraBiological Chemistry, Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia- Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Barcelona, Spain.ORCID http://orcid.org/0000-0002-6906-4833
Isabel HaroBiological Chemistry, Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia- Consejo Superior de Investigaciones Científicas (IQAC-CSIC), Barcelona, Spain.ORCID http://orcid.org/0000-0001-8677-2340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A substantial proportion of individuals with palindromic rheumatism develop rheumatoid arthritis (RA). This randomized, open-label, multicenter trial aimed to assess whether 2 years of treatment with abatacept (n = 34; 125 mg subcutaneous injections weekly during the first year and every 2 weeks during the second year) compared with oral hydroxychloroquine (n = 36; 5 mg kg

Indexed as

AbataceptAntirheumatic AgentsArthritis, RheumatoidHydroxychloroquineAdultFemaleHumansMaleMiddle AgedRheumatoid FactorTreatment OutcomeAbataceptAntirheumatic AgentsHydroxychloroquineRheumatoid Factor

Identifiers

PMID42135532
PMCPMC13375639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.