ArticleLeukemia2026
Local oxygen tension dictates hematopoietic cell growth and potency.
James Ropa, Sarah Gutch, Lindsay Wathen, So Jeong Kim, Jimin Park, Jessica Newton, Gracie Whitacre, Arafat Aljoufi, Scott Cooper, Wouter Van't Hof and 2 more
Abstract read
In one paragraphArticle in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Sarah GutchDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Lindsay WathenDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
So Jeong KimDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Jimin ParkDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Jessica NewtonDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Arafat AljoufiDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Scott CooperDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Maegan L CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. malcapit@iu.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MHematology Central Coordinating Center (HCCC) for the NIDDK Hematology Centers ProgramU24DK126127 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, DEREK L STIREWALT · 2020 to 2026
$7.5MOmics interrogation of functionally competent hematopoieitic stem cellsR00HL166790 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI James Patrick Ropa · 2025 to 2026
$497kOmics interrogation of functionally competent hematopoieitic stem cellsK99HL166790 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ROPA, JAMES PATRICK · 2023 to 2023
$106kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA082709NHLBI NIH HHS K99 HL166790NHLBI NIH HHS R00 HL166790NIDDK NIH HHS U24 DK126127NIDDK NIH HHS U54 DK106846U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U24 DK126127 Subaward 10055841-46-IU
6 · The paper itselfAbstract
Hematopoietic stem and progenitor cells support a lifetime supply of blood and immune cells and constitute a powerful cell therapy platform for hematologic diseases. In this study, we define oxygen-dependent activities of hematopoietic stem and progenitor cells. We found that lineage-defined progenitor cells from umbilical cord blood, bone marrow, and mobilized peripheral blood showed increased expansion in high oxygen, while primitive cells- including those from cord blood with in vivo potency- were maintained at higher frequencies in low physiologic O
Indexed as
HematopoiesisHematopoietic Stem CellsOxygenAnimalsCell ProliferationFetal BloodGene Expression ProfilingHumansSignal TransductionTranscriptomeOxygen
Identifiers
PMID42135527
PMCPMC13308678
What OpenQuestion holds
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