Evidence map›Paper›PMID 42135514›Full record

ArticleMolecular systems biology2026

Cross-species insights from ART-D to uncover evolutionarily conserved oncogenic mechanisms.

Yifan Guo, Jiadong Zheng, Yixin Wu, Kun Zhao, Dian Lv, Wenhan Liu, Mengling Wang, Jin-Yu Lu, Wenyan Xu, Xianping Wang and 1 more

Abstract read
In one paragraph

Article in Molecular systems biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yifan Guo *Fudan University, Shanghai, China. guoyifan@westlake.edu.cn.ORCID http://orcid.org/0000-0001-6551-2945
Jiadong Zheng *State Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.
Yixin WuState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0009-0001-9195-0364
Kun ZhaoState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.
Dian LvState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.
Wenhan LiuState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.
Mengling WangState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China.
Jin-Yu LuDepartment of Oncology, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Wenyan XuState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China. xuwenyan@westlake.edu.cn.ORCID http://orcid.org/0000-0002-8108-3463
Xianping WangState Key Laboratory of Gene Expression, School of Life Sciences, Westlake University, Hangzhou, China. wangxianping@westlake.edu.cn.ORCID http://orcid.org/0009-0004-7405-0585
Xianjue MaFudan University, Shanghai, China. maxianjue@westlake.edu.cn.ORCID http://orcid.org/0000-0003-4360-3947

Funding

HRHI program of Westlake Laboratory of Life Sciences and Biomedicine 1011103360222B1MOST | National Natural Science Foundation of China (NSFC) 32170824MOST | National Natural Science Foundation of China (NSFC) 32322027Natural Science Foundation of Hangzhou 2025SZRJJ0011State Key Laboratory of Genetic Expression ZX-2025004Zhejiang Provincial Natural Science Foundation Project LQKWL26C0701
6 · The paper itself

Abstract

Cancer arises from oncogenic clones, yet the dynamic mechanisms driving their stepwise evolution toward malignancy remain incompletely understood. Here, we establish the Atlas of Ras-driven Tumors in Drosophila (ART-D), a systematic, cross-species platform that dissects the molecular and phenotypic trajectories of tumorigenesis across ten genetically defined Ras

Indexed as

CarcinogenesisNeoplasmsAnimalsDrosophila melanogasterDrosophila ProteinsEvolution, MolecularGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNF-kappa BOncogenesras ProteinsReceptors, NotchSignal TransductionSpecies SpecificityDrosophila ProteinsNF-kappa Bras ProteinsReceptors, Notch

Identifiers

PMID42135514
PMCPMC13433787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.