ArticleNature methods2026
Unraveling lncRNA diversity at a single cell resolution and in a spatial context across different cancer types.
Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Decoding the functional landscape of long non-coding RNAs in hepatocellular carcinoma: molecular mechanisms, clinical implications, and therapeutic prospects.Journal of the Egyptian National Cancer Institute · 2026Review
- BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans.Molecular cancer · 2026Article
- Review
- Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues.The Journal of pathology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Long noncoding RNAs (lncRNAs) participate in gene regulation underlying development and disease. Overcoming inherent limitations of bulk sequencing lncRNA analysis, we leveraged single-cell and spatial transcriptomics (ST) data to analyze 219,442 potential lncRNAs identified by the TAR-scRNA-seq pipeline across 13 cancer types. The lncRNA functions were assessed by identifying their cell-type specificity and spatial distributions across different tissue regions. Comparing with five existing databases, we confirmed shared lncRNAs and found 94,795 unannotated lncRNAs. The identified lncRNAs were experimentally validated across seven cancer types using three single-cell-resolution ST platforms and two long-read ST sequencing methods, encompassing both targeted and untargeted approaches. Genome-wide colocalization of lncRNAs with regulatory features, disease variants and pairwise spatial autocorrelation with protein-coding genes suggest potential functional roles. We built a free, fast and user-friendly database 'SPanC-Lnc' on AWS cloud. SPanC-Lnc will enable discovery of potentially functional lncRNAs specific for cell populations within heterogeneous tissues, providing new biological insights.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.