The association between the T allele in rs204076 and treatment retention in patients receiving medication for opioid use disorder.

Alannah McEvoy, Myanca Rodrigues, Jacqueline Hudson, David C Marsh, Lehana Thabane, Zainab Samaan

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Alannah McEvoyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., L8N 3K7, Hamilton, ON, Canada.

Myanca RodriguesDepartment of Psychiatry, Queens University, 752 King St. W., K7L 7X3, Kingston, ON, Canada.

Jacqueline HudsonDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, 100 West 5th St., L8N 3K7, Hamilton, ON, Canada.

David C MarshNOSM University, 935 Ramsey Lake Rd., P3E 2C6, Sudbury, ON, Canada.

Lehana ThabaneDepartment of Health Research Method, Evidence & Impact, 1280 Main St. W, L8S 4L8, Hamilton, ON, Canada.

Zainab SamaanDepartment of Psychiatry, Queens University, 752 King St. W., K7L 7X3, Kingston, ON, Canada. z.samaan@queensu.ca.

Funding

CIHR PJT-156306

6 · The paper itself

Abstract

Opioid Use Disorder (OUD) is a chronic condition for which Medications for Opioid Use Disorder (MOUD) are crucial. Methadone Maintenance Treatment (MMT) and buprenorphine/naloxone (BN) are MOUD used to decrease opioid cravings and use, however, retention rates for MMT and BN vary. Genetic factors associated with retention in patients with other MOUD are largely unknown. The objective was to investigate the role of the T allele in rs204076 (found within Opioid Receptor Delta 1 gene) as a predictor for treatment retention in MOUD. Data were collected for the Pharmacogenetics of Opioid Substitution Treatment Response (POST) project. Retention time was calculated from the reported time of initiation of MOUD until loss to follow up or completion 12 month follow up using Kaplan-Meier survival analyses. A Cox regression analysis was conducted based on predictor variables for MOUD treatment retention. Of patients on MOUD(n = 1,607), majority were male (57%) and with an average age of 40 years. Survival time did not differ among carriers of the rs204076 T allele (p = 0.24). When controlling for non-genetic factors, individuals with the T allele had a 40% lower hazard of leaving treatment (Hazard Ratio [HR] = 0.60, 95% Confidence Interval [CI] = 0.44, 0.84, p = 0.002). MMT was associated with a 56% lower hazard of leaving treatment compared to BN (HR = 0.44, CI = 0.34, 0.58, p = 1.07 × 10

Indexed as

Opiate Substitution TreatmentOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, deltaAdultAllelesBuprenorphine, Naloxone Drug CombinationFemaleHumansKaplan-Meier EstimateMaleMethadoneBuprenorphine, Naloxone Drug CombinationMethadoneOPRD1 protein, humanReceptors, Opioid, deltaBuprenorphineMethadoneOpioid use disorderPredictorsRetention

Identifiers

PMID42135448

DOI10.1038/s41598-026-52706-1

PMCPMC13365242

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.