Evidence map›Paper›PMID 42135381›Full record

ArticleScientific reports2026

Phytochemical profiling, green synthesis of Ag, Cu, Fe, and Zn nanoparticles, and in vitro biological activities of Delphinium brunonianum Royle.

Sajjad Azam, Amjad Hussain, Muhammad Sajid Hamid Akash, Khayala Mammadova, Saman Zahra, Muhammad Imran, Iftikhar Ali, Ismayil Gafarov, Abdur Rauf, Mohamed AbdElrahman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sajjad AzamDepartment of Chemistry, University of Okara, Okara, 56300, Pakistan.
Amjad HussainDepartment of Chemistry, University of Okara, Okara, 56300, Pakistan. amjadhussain@uo.edu.pk.
Muhammad Sajid Hamid AkashDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Khayala MammadovaMedical and Biological Physics Department, Azerbaijan Medical University, Baku, Azerbaijan.
Saman ZahraDepartment of Biology, University of Okara, Okara, 56300, Pakistan.
Muhammad ImranDepartment of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 960, 61421, Abha, Saudi Arabia.
Iftikhar AliDepartment of Chemistry, Karakoram International University, Gilgit, Pakistan.
Ismayil GafarovMedical and Biological Physics Department, Azerbaijan Medical University, Baku, Azerbaijan.
Abdur RaufDepartment of Chemistry, University of Swabi, Anbar, KP, Pakistan.
Mohamed AbdElrahmanCollege of Pharmacy, Al-Mustaqbal University, Babylon, 51001, Iraq.
Nada H AljarbaDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Alaa IsmailSchool of Medicine, Taif University, Taif, Saudi Arabia.
Katabathini NarasimharaoDepartment of Chemistry, Faculty of Science King, Abdulaziz University (KAU), P.O.Box 80203, 21589, Jeddah, Saudi Arabia.
Shagufta KamalDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.

Funding

This work was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R62), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia PNURSP2025R62
6 · The paper itself

Abstract

Delphinium brunonianum Royle (Ranunculaceae) is medicinally important species that has a diverse phytochemical profile and pharmacological potential. This study aimed to investigate phytochemicals, green synthesis of nanoparticles, and in vitro biological activities of Delphinium brunonianum extracts. GC-MS study of n-hexane, ethyl acetate, and dichloromethane extracts verified the existence of various bioactive phytochemicals. Green synthesis of Ag, Cu, Fe, and Zn nanoparticles was determined using UV-Vis spectroscopy, XRD, FT-IR, and SEM. Biological analysis showed that ethyl acetate extract and Ag nanoparticles exhibited radical scavenging activity, showing 93.43% and 66.99% inhibition, respectively. Acetylcholinesterase inhibition was high in n-hexane extract with 57.56%, whereas lipase inhibition was predominant in Cu and Fe nanoparticles with 72.52% and 65.90% values, respectively. Inhibition of tyrosinase was high in Cu nanoparticles with a 78.18% value, but inhibitory effect of α-amylase was high in crude extract with 49.06%. Zone of inhibition of n-hexane extract was 21.66 mm and Zn nanoparticles had 27.3 mm in antibacterial and antifungal activities, respectively. The results suggest that D. brunonianum is a potential source of bioactive phytochemicals and an effective green matrix for the synthesis of nanoparticles to support its possible implication in medical-related fields in future.

Indexed as

DelphiniumMetal NanoparticlesPhytochemicalsAnti-Bacterial AgentsAntioxidantsCholinesterase InhibitorsCopperGreen Chemistry TechnologyIronMonophenol MonooxygenasePlant ExtractsSilverSpectroscopy, Fourier Transform InfraredZincAnti-Bacterial AgentsAntioxidantsCholinesterase InhibitorsCopperIronMonophenol MonooxygenasePhytochemicalsPlant ExtractsSilverZincAntioxidant activityDelphinium brunonianumEnzyme inhibitionGC–MS analysisGreen synthesisMetal nanoparticles

Identifiers

PMID42135381
PMCPMC13369400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.