Evidence map›Paper›PMID 42135304›Full record

Articlenpj aging2026

Neural signatures of dual-task walking demands in individuals at risk of cognitive impairment.

Pierfilippo De Sanctis, Denis Barbusse, Theo Vanneau, Wenzhu B Mowrey, Maya A Hoff, Claudia Schneider, Jeannette R Mahoney, Johanna Wagner, John J Foxe, Sophie Molholm

Abstract read
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pierfilippo De SanctisDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY, USA. pierfilippo.sanctis@einsteinmed.edu.
Denis BarbusseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Theo VanneauThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Wenzhu B MowreyDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Maya A HoffDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Claudia SchneiderDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Jeannette R MahoneyDepartment of Neurology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, NY, USA.
Johanna WagnerZander Laboratories, Germany, The Netherlands.
John J FoxeThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
Sophie MolholmThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, NY, USA.

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
Biological and neural mechanisms of fallsR01AG044007 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2013 to 2017
$3.5M
Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
Neurobiological Substrates of Visual-Somatosensory Integration in AgingK01AG049813 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MAHONEY, JEANNETTE R. · 2016 to 2021
$818k
Cortical Underpinnings of Gait and Falls in Aging: A Novel Brain-Body Imaging ApproachK01AG049991 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DE SANCTIS, PIERFILIPPO · 2016 to 2021
$766k
National Institutes of Health, United States K01AG049991NIA NIH HHS K01 AG049813NIA NIH HHS K01AG049813NIA NIH HHS K01 AG049991NIA NIH HHS R01 AG036921NIA NIH HHS R01 AG044007NICHD NIH HHS P50 HD105352
6 · The paper itself

Abstract

Difficulties in complex daily activities are a hallmark of dementia syndromes. We examined neural signatures of complex daily activity using electroencephalography in forty-five older adults performing a dual-task walking paradigm. Participants were stratified by risk of cognitive impairment (CI). Brain activation linked to gait-related and cognitive events was recorded during single- and dual-task conditions. We hypothesized that a higher risk of CI is associated with poorer performance and distinct fronto-parietal activation during dual-task walking. Cognitive performance declined during walking, with individuals at higher risk of CI performing worse. Increased brain activity during the cognitive task was associated with a lower risk of CI. Both groups showed increased gait-related activation of sensorimotor and fronto-medial cortices during dual-task walking; however, greater sensorimotor activation was observed in individuals at higher risk of CI. Neural signatures of complex daily activity may help identify early signs of cognitive decline and inform prevention strategies.

Identifiers

PMID42135304
PMCPMC13415884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.