Evidence map›Paper›PMID 42135288›Full record

ReviewBDJ open2026

Adipokines in oral squamous cell carcinoma-a narrative overview.

Pavithra Velusamy, Mary Mathew, Adarsh Kudva, Chetana Chandrashekar, Srikanth Gadicherla, Yoithaprabhunath Thuckanaickenpalayam Ragunathan, Sri Chinthu Kenniyan Kumar, Monica Charlotte Solomon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BDJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pavithra VelusamyDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Mary MathewDepartment of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Adarsh KudvaDepartment of Oral and Maxillofacial Surgery, Manipal College Of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Chetana ChandrashekarDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Srikanth GadicherlaDepartment of Oral and Maxillofacial Surgery, Manipal College Of Dental Sciences, Manipal Academy of Higher Education, Manipal, India.
Yoithaprabhunath Thuckanaickenpalayam RagunathanDepartment Of Oral and Maxillofacial Pathology and Oral Microbiology, Vivekanandha Dental College for Women, Namakkal, Tamil Nadu, India.ORCID http://orcid.org/0000-0001-6084-369X
Sri Chinthu Kenniyan KumarDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KSR Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India.
Monica Charlotte SolomonDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, India. monica.charlotte@manipal.edu.ORCID http://orcid.org/0000-0002-1836-887X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify and summarize the types of adipokines associated with Oral Squamous Cell Carcinoma (OSCC) pathogenesis and prognosis. MATERIALS AND

methodsA comprehensive literature search was done involving Scopus, PubMed, and Embase. Studies involving adipokines in OSCC conducted in humans were included.

resultsAdipokines have diverse and stage-dependent effects on OSCC, including regulation of inflammation, angiogenesis, hypoxia, and tumour progression. Adipokines such as chemerin, resistin, leptin, and apelin contribute to tumour progression. Zinc alpha-2-glycoprotein and adiponectin were found to be antitumourigenic in OSCC. Methodological heterogeneity and a lack of standardized outcome measures limit comparability across studies to establish the definitive role of adipokines in OSCC.

conclusionAdipokines shape OSCC biology through diverse, stage-specific mechanisms, making them potential biomarkers of disease progression. The adipokines reported in OSCC require validation through long-term prospective studies and addressing methodological heterogeneity to serve as prognostic markers.

Identifiers

PMID42135288
PMCPMC13176341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.