ReviewAnesthesia and pain medicine2026
Postoperative delirium: from bundles to precision prevention.
Review in Anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Perioperative brain health, encompassing postoperative delirium (POD) and longer-lasting cognitive decline, has become a major priority for patient safety and quality of recovery in older surgical patients. The 2018 unified nomenclature introduced perioperative neurocognitive disorders as an umbrella term spanning pre-existing neurocognitive disorder, POD, delayed neurocognitive recovery, and postoperative neurocognitive disorder. The incidence of POD varies widely, reflecting differences in age, baseline cognition, surgical type, and ascertainment; however, its clinical footprint is consistently substantial, with increased mortality, longer hospitalization, and downstream cognitive deterioration. Electroencephalography (EEG)-guided anesthesia trials have yielded mixed results, favoring its integration with hemodynamic optimization and medication stewardship. Screening uptake remains < 10% in many settings, limiting the ability to provide scalable and equitable brain care. Current prevention standards prioritize multicomponent, non-pharmacological bundles such as mobilization, reorientation/cognitive stimulation, sleep promotion, sensory optimization, hydration, nutrition, oxygen delivery, and prompt management of precipitating factors. Nonetheless, translation to "precision prevention" is constrained by three gaps: low implementation of recommended screening pathways, heterogeneity and limited transportability of prognostic models, and an under-operationalized vulnerability domain in which frailty and malnutrition lack standardized tools, cut-offs, and linked interventions. Biomarkers and perioperative physiology including EEG suppression patterns and individualized perfusion targets are biologically coherent adjuncts for risk refinement; however, current evidence supports their use as additive stratifiers within bundles rather than stand-alone gatekeepers. Next-generation perioperative brain health studies should standardize vulnerability phenotyping, integrate evidence-based selective monitoring and biomarker-informed refinement, and embed these elements into scalable workflows that convert guidelines into practical bedside actions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.