Evidence map›Paper›PMID 42134984›Full record

ArticleThe European respiratory journal2026

Nasal nitric oxide combined with clinical features for preliminary screening of primary ciliary dyskinesia in bronchiectasis.

Shunlian Hu, Xiyue Shen, Jiayi Wang, Haiwen Lu, Yang Liu, Shuyi Gu, Ai Ge, Jiawei Yang, Bei Mao, Felix C Ringshausen and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shunlian HuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiyue ShenDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiayi WangInstitute of Respiratory Medicine, School of Medicine, Tongji University, Shanghai, China.
Haiwen LuDepartment of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yang LiuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shuyi GuDepartment of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Ai GeDepartment of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiawei YangDepartment of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Bei MaoDepartment of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Felix C RingshausenDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0001-9084-4968
Amelia ShoemarkDepartment of Respiratory and Gastroenterology, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0001-7360-6060
Jin-Fu XuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China jfxucn@163.com.ORCID https://orcid.org/0000-0002-8039-8973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePrimary ciliary dyskinesia (PCD), an underdiagnosed genetic disorder characterised by dysfunctional cilia, is a known cause of bronchiectasis.

objectivesTo prospectively identify PCD among patients with bronchiectasis using nasal nitric oxide (nNO) and clinical features, and to characterise genetic features.

methodsThis cross-sectional study enrolled adolescent and adult patients with bronchiectasis from the BE-China registry at Shanghai Pulmonary Hospital. Individuals with either strong clinical suspicion or nNO ≤77 nL·min

resultsAmong 373 patients with bronchiectasis, 27 (7.4%) were in the PCD group (14 "confirmed PCD" and 13 "PCD highly likely"). nNO showed high screening accuracy (sensitivity 84.8%, specificity 97.1%). Patients with PCD were younger and had earlier bronchiectasis onset. Age-adjusted regression analysis showed independent associations between PCD and lower body mass index (regression coefficient (RC) -1.5, 95% CI -2.9 to -0.1), forced expiratory volume in 1 s (FEV

conclusionsPatients with PCD had more severe disease, reinforcing the need for structured screening in patients with bronchiectasis. nNO combined with clinical features is an effective and reliable screening strategy for PCD in bronchiectasis.

Indexed as

BronchiectasisKartagener SyndromeNitric OxideAdolescentAdultAxonemal DyneinsBreath TestsChildChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective StudiesRegistriesAxonemal DyneinsDNAH11 protein, humanNitric Oxide

Identifiers

PMID42134984
PMCPMC13650444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.