Evidence map›Paper›PMID 42134983›Full record

ArticleThe European respiratory journal2026

The Third PLeural Effusion And Symptom Evaluation (PLEASE-3) study: bendopnoea in patients with pleural effusion.

Bianca M Iacopetta, Bapti Roy, Charley A Budgeon, Michaela Donaghy, Matthew Ing, Chloe Charlesworth, Carolyn J Peddle-McIntyre, Ai Ling Tan, Kevin Murray, Y C Gary Lee

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Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bianca M IacopettaInstitute for Respiratory Health, Pleural Medicine Unit, Perth, Australia.ORCID https://orcid.org/0009-0003-7510-5261
Bapti RoyExercise Medicine Research Institute, Edith Cowan University, Perth, Australia.
Charley A BudgeonSchool of Population and Global Health, University of Western Australia, Perth, Australia.
Michaela DonaghyDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Australia.ORCID https://orcid.org/0009-0008-9745-0214
Matthew IngInstitute for Respiratory Health, Pleural Medicine Unit, Perth, Australia.
Chloe CharlesworthCentre for Innovative Pleural Research, Sir Charles Gairdner Hospital, Perth, Australia.
Carolyn J Peddle-McIntyreInstitute for Respiratory Health, Pleural Medicine Unit, Perth, Australia.ORCID https://orcid.org/0000-0001-9913-4022
Ai Ling TanInstitute for Respiratory Health, Pleural Medicine Unit, Perth, Australia.
Kevin MurraySchool of Population and Global Health, University of Western Australia, Perth, Australia.
Y C Gary LeeInstitute for Respiratory Health, Pleural Medicine Unit, Perth, Australia gary.lee@uwa.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBendopnoea (breathlessness on bending forward) is reported often by patients with pleural effusion, but its prevalence and clinical relevance are unexplored.

methodsThis study prospectively enrolled unselected patients with pleural effusion. Bendopnoea was assessed by time to breathlessness when bending patients forward for up to 60 s (60-s bend test (60s-BT)). Post-hoc analyses using a 30-s cut-off were also conducted.

results200 patients (median age 72 years; 61% male) were included; n=88 underwent therapeutic drainage (median (interquartile range (IQR)) 1.50 (1.11-2.47) L). Effusions were commonly malignant (42%) and occupied >25% of the hemithorax (74%). Most patients had bendopnoea on the 60s-BT (56%) and reported it "impacted daily activities" (74%). The estimated median time to bendopnoea was 43 (95% CI 30-59) s. Bendopnoea was more common with larger pleural effusions on chest radiographs (p=0.0332 using 60-s cut-off and p=0.0217 using 30-s cut-off). Patients with bendopnoea on the 60s-BT were more breathless (median (IQR) 48 (22-67)

conclusionBendopnoea is a simple and worthwhile symptom to recognise in patients with pleural effusion.

Indexed as

DyspneaPleural EffusionAgedAged, 80 and overDrainageFemaleHumansMaleMiddle AgedProspective StudiesRadiography, ThoracicSymptom Assessment

Identifiers

PMID42134983
PMCPMC13650443

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