ArticleVox sanguinis2026
Iron recovery dynamics after whole blood donation and the effect of low-dose iron supplementation in Japanese donors.
Article in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIron deficiency (ID) poses a non-negligible risk for blood donors, yet longitudinal data on iron status and whether low-dose iron-containing supplements improve ID among Japanese donors are scarce. This study aimed to elucidate these issues. MATERIALS AND
methodsSixty-six healthy Japanese donated 400 mL of whole blood (WB) and underwent scheduled blood samplings. Fourteen participants discontinued follow-up; 52 donors completed the second 400 mL WB donation at Week 48. Participants were subsequently provided supplements containing 6 mg/day of ferric citrate for 12 weeks, with continued monitoring through Week 48; the total duration of participation in the study was 96 weeks. Haematological data were analysed using a linear mixed-effects model.
resultsIn men, serum ferritin (sFer) declined from 116.2 ng/mL (95% confidence interval [95% CI]: 88.0-144) to 83.7 ng/mL (55.5-112) at Week 4 and returned to baseline by Week 36. In women, sFer decreased from 29.2 ng/mL (21.74-36.7) to 16.6 ng/mL (9.16-24.1) at Week 4 and returned to baseline at Week 24. Recovery of sFer was slower than that of haemoglobin (Hb) in both sexes. Iron supplementation did not affect the recovery of Hb and sFer in men and Hb in women, whereas women showed a significant increase in sFer at Week 16.
conclusionAlthough Hb recovered quickly after 400 mL WB donation, replenishment of iron stores took longer. Low-dose iron supplementation facilitated the recovery of iron stores in women. These findings highlight the need for monitoring iron status and may inform strategies to support donor safety and maintain adequate blood supply.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.