Evidence map›Paper›PMID 42134539›Full record

Observational studyBrazilian journal of anesthesiology (Elsevier)

Coronary artery bypass grafting in Jehovah's Witness patients: a retrospective propensity matched cohort study.

Henrique Ryu Yamanaka Nakano, Guilherme Mota Filho, Bruno Camargo Calabria Araújo, Heloísa Zogheib, Enzo Camargo Calabria Araújo, Leonardo Cardoso Saraiva, Jessica Silva Nicolau, Suely Pereira Zeferino, José Otávio Costa Auler Junior

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Henrique Ryu Yamanaka NakanoHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil. Electronic address: nakanohenrique@gmail.com.
Guilherme Mota FilhoHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil.
Bruno Camargo Calabria AraújoHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil.
Heloísa ZogheibHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil.
Enzo Camargo Calabria AraújoHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil.
Leonardo Cardoso SaraivaHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Anesthesiology Institute of Surgery Department, São Paulo, SP, Brazil.
Jessica Silva NicolauHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Heart Institute, São Paulo, SP, Brazil.
Suely Pereira ZeferinoHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Heart Institute, São Paulo, SP, Brazil.
José Otávio Costa Auler JuniorHospital de Clínicas da Faculdade de Medicina da Universidade de São Paulo, Heart Institute, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary Artery Bypass Grafting (CABG) in Jehovah's Witness (JW) patients raises concerns regarding perioperative safety because of refusal of allogeneic blood transfusions. This study evaluated the feasibility and short-term outcomes of CABG in JW patients and described perioperative blood management practices.

methodsThis retrospective observational study included 26 JW patients and 78 matched non-Jehovah's Witness (non-JW) patients who underwent CABG at InCor HC-FMUSP between 2015 and 2023. Propensity score matching at a 3:1 ratio based on age, sex, and preoperative hemoglobin was used to improve comparability. The primary outcome was 30-day all-cause mortality. Secondary outcomes included 30-day stroke, myocardial infarction, and acute kidney injury; ICU length of stay; perioperative red blood cell transfusion rates; postoperative hemoglobin and hematocrit; intraoperative blood loss; and cardiopulmonary bypass time.

resultsNo 30-day deaths occurred among JW patients, whereas three deaths occurred in the non-JW group (OR = 0.45; 95% CI 0.003-5.09; p = 0.575). No JW patient experienced stroke, and one myocardial infarction occurred. JW patients had higher postoperative hemoglobin (OR = 1.50; 95% CI 1.03-2.28; p = 0.032) and lower intraoperative blood loss (OR = 0.55; 95% CI 0.27-0.98; p = 0.046). No JW patient received transfusion, whereas 17.9% and 12.8% of non-JW patients required intraoperative and postoperative transfusions, respectively. ICU length of stay was similar between groups.

conclusionIn this cohort, CABG in JW patients was feasible with acceptable short-term outcomes. Outcomes were generally comparable between groups, acknowledging imprecision related to the small JW sample.

Indexed as

Blood TransfusionCoronary Artery BypassJehovah's WitnessesAgedBlood Loss, SurgicalCohort StudiesFeasibility StudiesFemaleHumansLength of StayMaleMiddle AgedPropensity ScoreRetrospective StudiesTreatment OutcomeBlood component transfusionCoronary artery bypassJehovah’s WitnessesPerioperative careTransfusion-free surgery

Identifiers

PMID42134539
PMCPMC13285268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.