Evidence map›Paper›PMID 42134318›Full record

ArticleCell reports2026

ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic T

Sydney B Crotts, Jackson T Barnes, Regina M Antonetti, Michael J Shapiro, Naomi M Gades, William A Faubion, Kathryn A Knoop, Virginia Smith Shapiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sydney B CrottsGraduate School of Biomedical Science, Mayo Clinic, Rochester, MN, USA; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Jackson T BarnesDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Regina M AntonettiDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Michael J ShapiroDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Naomi M GadesDepartment of Comparative Medicine, Mayo Clinic, Phoenix, AZ, USA.
William A FaubionDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Phoenix, AZ, USA.
Kathryn A KnoopGraduate School of Biomedical Science, Mayo Clinic, Rochester, MN, USA; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Virginia Smith ShapiroGraduate School of Biomedical Science, Mayo Clinic, Rochester, MN, USA; Department of Immunology, Mayo Clinic, Rochester, MN, USA. Electronic address: shapiro.virginia1@mayo.edu.

Funding

ST8Sia6 expression on tumors inhibits the immune responseR01CA243545 · NCI · MAYO CLINIC ROCHESTER · PI SHAPIRO, VIRGINIA SMITH · 2020 to 2024
$2.1M
NCI NIH HHS R01 CA243545
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract. Pathogenesis of IBD is multifactorial and incompletely understood. Here, we show that the sialyltransferase ST8Sia6 regulates gut inflammation and homeostasis. ST8Sia6-deficient mice spontaneously accumulate activated immune cells in the small intestine and exhibit enhanced sensitivity to dextran sodium sulfate-induced colitis. ST8Sia6-knockout small bowel lamina propria T cells exhibit steady-state increases in T

Indexed as

InflammationSialyltransferasesTh17 CellsTh1 CellsAnimalsColitisDextran SulfateGlycosylationMiceMice, Inbred C57BLMice, Knockoutalpha-N-acetylneuraminate alpha-2,8-sialyltransferaseDextran SulfateSialyltransferasesautoimmunityCP: immunologyCrohn's diseaseglycosylationinflammationinflammatory bowel diseasesialylationsmall intestine

Identifiers

PMID42134318
PMCPMC13298801

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.