ArticleCell2026
A comparison of deep multiomics profiles across ethnicity, geography, and age.
Abstract readComparative Study
In one paragraph
Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
- Population proteomics for equitable precision medicine.EMBO molecular medicine · 2026Article
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Authors and funding
64 authors.
Nasim BararpourDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
John Z CaoDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Yue WuDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
Shubham GuptaDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Michael R HoopmannInstitute for Systems Biology, Seattle, WA 98109, USA.
Rui QinDepartment of Chemistry, University of Alberta, Edmonton, AB T6G2G2, Canada.
Mukul K MidhaInstitute for Systems Biology, Seattle, WA 98109, USA.
Myriam MireaultDepartment of Chemistry/CERMO-FC, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
Pablo Juanes-VelascoInstitute of BioMedical Research of Salamanca (IBSAL), IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain.
Casey HansonDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Sara AhadiDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Emily HiggsDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
David H BaxterInstitute for Systems Biology, Seattle, WA 98109, USA.
Christian DienerInstitute for Systems Biology, Seattle, WA 98109, USA; Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Orit Dagan-RosenfeldDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Daniel HornburgDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Songjie CheDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Fredrik EdforsDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Stephanie J ChurchDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Mohan BabuDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Durga ThotaDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Christopher JinDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Tristan ChouDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Shannon RegoDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Monika AvinaDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Lettie McGuireDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Jessi W LiDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Thomas KarathanosDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Daniel J PanyardDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA.
Martín A Acosta ParraDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Aubrey K RobertsDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Amarnath K RanjitDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Computer Science, School of Computing, Amrita Vishwa Vidyapeetham (University), Amritapuri, India.
Ekanath RanganDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA.
Jose Juan Almagro ArmenterosDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Melanie AshlandDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Kevin Erazo CastilloDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Gavin TraberDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Matthew EllenbergerDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Ryan KelloggDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Wenyu ZhouDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Hannes RostDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Martin KjellbergDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Tejaswini MishraDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Charu KapilInstitute for Systems Biology, Seattle, WA 98109, USA.
Ulrike KusebauchInstitute for Systems Biology, Seattle, WA 98109, USA.
Sushmita PatwardhanInstitute for Systems Biology, Seattle, WA 98109, USA.
Alicia Landeira-ViñuelaInstitute of BioMedical Research of Salamanca (IBSAL), IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain.
Angela-Patricia HernandezInstitute of BioMedical Research of Salamanca (IBSAL), IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain.
Mikkel Eggert ThomsenDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Maliha MashkoorDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Thanadol SutantiwanichkulScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Tea Dodig-CrnkovicScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Annika BendesScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Leo DahlScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Sean M GibbonsInstitute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA; eScience Institute, University of Washington, Seattle, WA 98105, USA.
P Venkat RanganAmrita Vishwa Vidyapeetham (University), Amritapuri, India.
Allan StensballeDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark. Electronic address: allan@stensballe.com.
Jochen M SchwenkScience for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden. Electronic address: jochen.schwenk@scilifelab.se.
Richard D UnwinDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Electronic address: r.unwin@manchester.ac.uk.
Manuel FuentesInstitute of BioMedical Research of Salamanca (IBSAL), IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain. Electronic address: mfuentes@usal.es.
Lekha SlenoDepartment of Chemistry/CERMO-FC, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada. Electronic address: sleno.lekha@uqam.ca.
Robert L MoritzInstitute for Systems Biology, Seattle, WA 98109, USA. Electronic address: rmoritz@systemsbiology.org.
Lara K MahalDepartment of Chemistry, University of Alberta, Edmonton, AB T6G2G2, Canada. Electronic address: lkmahal@ualberta.ca.
Michael P SnyderDepartment of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Stanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA. Electronic address: mpsnyder@stanford.edu.
Funding
VAST Center: Viromes Across Space(s) and TimeU54AG089334 · NIA · STANFORD UNIVERSITY · PI Christopher Edward Mason · 2025 to 2026
$13.3MNIA NIH HHS U54 AG089334
Abstract
Despite extensive research, molecular differences in human populations and the influence of ancestry, age, geography, and diet are poorly understood. We performed comprehensive multiomics profiling (including genomics, transcriptomics, proteomics, metabolomics, lipidomics, metallomics, glycomics, and microbiomics) on samples from 322 healthy individuals of European, East Asian, and South Asian ancestry across multiple continents. We identified ethnicity-associated molecular features linked to host metabolism, autoimmune disease risk, drug metabolism, and neurodegenerative pathways. We uncovered ancestry- and geography-related molecular changes affecting metabolism, immune function, microbiome composition, and biological aging. Specific genetic variants and gene expression differences were associated with lipid metabolism and immune regulation. Geography influenced biological age: East Asians showed lower biological age in their ancestral regions, whereas individuals of European ancestry exhibited lower biological age in the US/Canada than in Europe. Diet-microbiome metabolism interactions displayed ethnicity-specific patterns, many related to health. This open access resource advances understanding of ethnicity-environment interactions and supports precision medicine.
Indexed as
AgingEthnicityAdultCanadaDietEast Asian PeopleEuropeFemaleGenomicsGeographyHumansMaleMicrobiotaMiddle AgedMultiomicsProteomicsagingancestrydietethnicitygeographicalhealthintegrated analysismultiomicspopulationprecision medicine
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