Evidence map›Paper›PMID 42134227›Full record

ArticleThe journal of prevention of Alzheimer's disease2026

Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.

Jung Ki Kim, Thalida E Arpawong, Bharat Thyagarajan, Jennifer A Smith, Sithara Vivek, Scott Ratliff, Sharmistha Dey, Jinkook Lee, Eileen M Crimmins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jung Ki KimDavis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: jungk@usc.edu.
Thalida E ArpawongDavis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Sithara VivekDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Scott RatliffSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Sharmistha DeyDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Jinkook LeeDepartment of Economics and Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Eileen M CrimminsDavis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and DementiaR01AG068405 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS, CRIMMINS, EILEEN M · 2020 to 2024
$3.6M
Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRDRF1AG088003 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRIMMINS, EILEEN M, GROSS, ALDEN L. · 2024 to 2024
$2.4M
NIA NIH HHS R01 AG068405NIA NIH HHS RF1 AG088003
6 · The paper itself

Abstract

DNA methylation (DNAm)-based epigenetic clocks are emerging biomarkers of biological aging and have been linked to cognitive decline and dementia, but their relationship with blood-based neurodegenerative biomarkers remains understudied in low- and middle-income countries (LMIC). Using the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD), we examined whether epigenetic aging was associated with levels and changes in neurodegenerative biomarkers among adults aged ≥60 years. Seven epigenetic clocks were derived from DNAm data and related to plasma levels of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), phosphorylated tau 181 (pTau181), total tau, Amyloid-β (Aβ)42, Aβ40 and Aβ42/Aβ40 measured at two time points. Baseline accelerated epigenetic aging was associated with higher levels of neurodegenerative biomarkers, including pTau181, GFAP, and NfL, with more consistent associations with increases in GFAP and NfL for morbidity- and mortality-trained clocks. These findings support the utility of epigenetic clocks as scalable tools for identifying risk of neurodegeneration in LMIC settings.

Indexed as

AgingDementiaDNA MethylationEpigenesis, GeneticAgedAmyloid beta-PeptidesBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansIndiaLongitudinal StudiesMaleMiddle AgedNeurofilament Proteinstau ProteinsAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsDementiaDNA methylationEpigenetic agingLow- and middle-income countriesNeurodegeneration biomarkers

Identifiers

PMID42134227
PMCPMC13196560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.