Evidence map›Paper›PMID 42134200›Full record

ArticleEnvironment international2026

Prenatal and postnatal household air pollution and longitudinal growth trajectories: results from long-term follow up of the GRAPHS cohort.

Seyram Kaali, Martin Röösli, Tawfiq Yussif, Michelle Li, Mohammed Nuhu Mujtaba, James Ross, Prosper Donneyong, Peggy S Lai, Sule Awuni, Musah Osei and 7 more

Abstract read
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Seyram KaaliKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland. Electronic address: kaali.seyram@kintampo-hrc.org.
Martin RöösliSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Tawfiq YussifKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
Michelle LiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Mohammed Nuhu MujtabaKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
James RossLamont-Doherty Earth Observatory of Columbia University, New York, NY, United States.
Prosper DonneyongKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
Peggy S LaiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States.
Sule AwuniKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
Musah OseiKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
Elena ColicinoDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Yohannes TsefaigziBrigham and Women's Hospital, Harvard University, Massachusetts, MA, United States.
Steven ChillrudLamont-Doherty Earth Observatory of Columbia University, New York, NY, United States.
Darby JackDepartment of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY, United States.
Kwaku Poku AsanteKintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo, Bono East Region, Ghana.
Alison LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ami R Zota · 1998 to 2026
$44.7M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Child Lung Development Following a Cookstove Intervention: Evidence from GRAPHSR01ES026991 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Darby Jack, Alison G Lee · 2017 to 2026
$5.6M
Intervening to Improve Birth Weight and Infant Respiratory Health in Rural GhanaR01ES019547 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KINNEY, PATRICK LOTT · 2011 to 2016
$4.5M
Early life household air pollution, metal composition and cardiovascular health: Evidence from GRAPHSR01ES034433 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Darby Jack, Alison G Lee · 2022 to 2026
$3.5M
Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trialR01ES035791 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Darby Jack, Peggy Sue Lai · 2025 to 2026
$2.7M
The Ghana Randomized Air Pollution and Health Study (GRAPHS) CohortU24ES036007 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JACK, DARBY, KAALI, SEYRAM · 2024 to 2025
$687k
Circulating microRNAs in extracellular vesicles, household air pollution and lung development in GhanaR21TW010957 · FIC · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JACK, DARBY, LEE, ALISON G · 2018 to 2019
$375k
High Precision Robotic Weighing System in Support of New Exposure Health StudiesS10OD016219 · OD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHILLRUD, STEVEN N. · 2013 to 2013
$250k
FIC NIH HHS R21 TW010957NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES019547NIEHS NIH HHS R01 ES026991NIEHS NIH HHS R01 ES034433NIEHS NIH HHS R01 ES035791NIEHS NIH HHS U24 ES036007NIH HHS S10 OD016219
6 · The paper itself

Abstract

backgroundThere is limited evidence on the long-term effects of household air pollution (HAP) exposure during critical developmental windows and longitudinal growth trajectories in childhood.

methodsWe leveraged a longitudinal pregnancy cohort from rural communities in central Ghana with repeated personal monitoring of prenatal and postnatal carbon monoxide (CO) and fine particulates (PM

resultsPrenatal CO had the most consistent association with growth. Higher prenatal CO was associated with lower HAZ from age 1 through 9 with peak effect at age 4: adjusted β = -0.08; 95% CI = -0.12, -0.03; p = 0.002 per doubling), and WAZ from 7 through age 9 (peak effect was at age 9: adjusted β = -0.05; 95% CI = -0.09, -0.003; p = 0.04 per doubling). Results were similar for the ordered categories of HAZ and WAZ. Sex did not modify these associations.

conclusionsHigher HAP exposure, as indexed by prenatal CO during critical developmental windows may contribute substantially to long-term poor linear growth throughout childhood.

Indexed as

Air Pollution, IndoorChild DevelopmentPrenatal Exposure Delayed EffectsAir PollutantsCarbon MonoxideChildChild, PreschoolFemaleGhanaHumansInfantLongitudinal StudiesMaleParticulate MatterPregnancyAir PollutantsCarbon MonoxideParticulate MatterChild anthropometricsCritical windows of developmentHousehold air pollutionLongitudinal growth trajectoriesProspective birth cohort

Identifiers

PMID42134200
PMCPMC13348564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.