In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Nikita GudekarBond Life Sciences Center, University of Missouri, Columbia, MO 65211.
Chiemerie AzubuoguBond Life Sciences Center, University of Missouri, Columbia, MO 65211.
Martina RalleDepartment of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0001-7786-0242 María G MediavillaLaboratorio de Cofactores Metálicos en Tripanosomátidos, Instituto de Biología Molecular y Celular de Rosario, Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Rosario, Rosario 2000, Argentina.
Julia A CriccoLaboratorio de Cofactores Metálicos en Tripanosomátidos, Instituto de Biología Molecular y Celular de Rosario, Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Rosario, Rosario 2000, Argentina.ORCID 0000-0002-8993-3880 Natalie M GarzaDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843.
Vishal M GohilDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-9920-2563 Scott PeckBond Life Sciences Center, University of Missouri, Columbia, MO 65211.
Siddhartha KumarEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198.
Amarnath NatarajanEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198.
Madujika A Horadigala-GamageDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080.
Gabriele MeloniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0003-4976-1401 Kamal SinghBond Life Sciences Center, University of Missouri, Columbia, MO 65211.
Funding
Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5MTargeting vulnerabilities in copper metabolism in the development of cancer therapiesR01CA262664 · NCI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2021 to 2025
$2.3MNovel roles of copper in adaptive responses to hypoxiaR01DK131190 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2021 to 2025
$2.1MMitochondrial Copper BiologyR35GM152102 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Vishal Mahendrasingh Gohil · 2024 to 2026
$1.7MICP-MS to Measure Elemental ConcentrationsS10RR025512 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2009 to 2009
$168kHHS | NIH | National Cancer Institute (NCI) R01CA262664HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK131190HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM128704HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM152102NCI NIH HHS R01 CA262664NCRR NIH HHS S10 RR025512NIDDK NIH HHS R01 DK131190NIGMS NIH HHS R35 GM128704NIGMS NIH HHS R35 GM152102
6 · The paper itselfAbstract
Copper (Cu) transporting ATPases represent a highly conserved subclass of P-type ATPases with critical roles in Cu export and metalloenzyme synthesis. Despite their important biological roles and association with a wide range of human diseases, no high-affinity small-molecule inhibitors have been described. Here, we identify MKV3 as a small molecule inhibitor of Cu-transporting P-type ATPases that targets a conserved Cu
Indexed as
CopperCopper-Transporting ATPasesAdenosine TriphosphatasesAnimalsBinding SitesEscherichia coliEscherichia coli ProteinsHumansMolecular Docking SimulationAdenosine TriphosphatasesATP7A protein, humancopA protein, E coliCopperCopper-Transporting ATPasesEscherichia coli Proteinsantimicrobial coppercopper pumpscopper transport inhibitioncuproptosisP1B-type ATPases
Identifiers
PMID42133807
PMCPMC13187769
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