Evidence map›Paper›PMID 42133765›Full record

ArticleScience (New York, N.Y.)2026

Improve genetic quality control to increase rigor and reproducibility of mouse research.

Fernando Pardo-Manuel de Villena, James M Amos-Landgraf, Timothy A Bell, Matthew W Blanchard, Jennifer Brennan, Charisse Carlson, Dominic J Ciavatta, Paul A Cotney, Martin T Ferris, Pablo Hock and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Fernando Pardo-Manuel de VillenaDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
James M Amos-LandgrafMMRRC-MU, Department of Pathobiology and Integrative Biosciences, University of Missouri, Columbia, MO, USA.
Timothy A BellDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Matthew W BlanchardDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Jennifer BrennanMMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.
Charisse CarlsonMMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.
Dominic J CiavattaDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Paul A CotneyDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Martin T FerrisDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Pablo HockDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Ian KorfMMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.
K C Kent LloydDepartment of Molecular and Cellular Biology, College of Biological Sciences, UC-D, Davis, CA, USA.
Cathleen LutzThe Jackson Laboratory, Bar Harbor, ME, USA.
Rachel M LynchDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Terry MagnusonDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Stephen A MurrayThe Jackson Laboratory, Bar Harbor, ME, USA.
Samit PatelMMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.
Laura G ReinholdtThe Jackson Laboratory, Bar Harbor, ME, USA.
John Sebastian SigmonMMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.
Brandon WillisMMRRC-UC Davis and Mouse Biology Program, UC-D, Davis, CA, USA.
James G XenakisDepartment of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
The Mutant Mouse Resource and Research Center at the University of Missouri - ResourceU42OD010918 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI James Amos-Landgraf · 2012 to 2026
$25.1M
Resource Section - Core 001U42OD010924 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TERRY R MAGNUSON · 2012 to 2026
$24.5M
The UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry · 2020 to 2026
$22.2M
The Mutant Mouse Resource and Research Center at The Jackson LaboratoryU42OD010921 · OD · JACKSON LABORATORY · PI LAURA G REINHOLDT · 2012 to 2026
$21.4M
MMRRC Informatics, Coordination, and Service Center at UC DavisU42OD010983 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$12.9M
NCI NIH HHS P30 CA093373NIEHS NIH HHS P42 ES031007NIH HHS U42 OD010918NIH HHS U42 OD010921NIH HHS U42 OD010924NIH HHS U42 OD010983NIH HHS U42 OD012210
6 · The paper itself

Abstract

A quality control process using the latest technology can help address inconsistencies and expectations.

Indexed as

Animal ExperimentationMice, Mutant StrainsQuality ControlAnimalsMiceReproducibility of Results

Identifiers

PMID42133765
PMCPMC13215183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.