ArticlePloS one2026
Multivariate genetic architecture of age-related eye disease.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
At present, the genetic architecture underlying traits linked to Age-related eye disease (ARED) remains largely unexplored. We utilized Genomic Structural Equation Modeling (Genomic-SEM) and various Post-processing analysis of Genome-Wide Association Studies (GWAS) to identify statistically prioritized candidate single nucleotide polymorphisms (SNPs) associated with independent ARED variants. A total of 11 genome-wide significant loci were identified in the study. By applying diverse transcriptome-wide association approaches, we analyzed tissue-, cell layer-, and genomic element-associated gene signals reflecting age-related ocular vulnerabilities, alongside their functional annotations in relation to ARED. Through conducting a GWAS on a phenotype not directly measured, our research presents the first comprehensive genetic landscape of ARED.
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