Evidence map›Paper›PMID 42133645›Full record

ArticlePloS one2026

First-passage-based boundary estimation in functional data.

Ahmet Tugay Kuzu, Nuri Celik

Abstract read
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ahmet Tugay KuzuDepartment of Mathematics, Gebze Technical University, Kocaeli‌‌, Turkey.
Nuri CelikDepartment of Mathematics, Gebze Technical University, Kocaeli‌‌, Turkey.ORCID https://orcid.org/0000-0002-4234-2389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We study a functional threshold-crossing setting in which a population-level boundary evolves smoothly over time and crossing events are observed through subject-specific functional trajectories. Motivated by biomedical and environmental applications where brief excursions above a critical level may trigger risk activation, we formulate boundary recovery as a first-passage identification problem and propose a practical estimation strategy based on smoothing observed crossing pairs. The boundary is represented using penalized cubic B-splines with roughness control, and tuning parameters are selected by generalized cross-validation. We further emphasize the distinction between (i) a time-varying benchmark used to define first-passage times and (ii) a reconstructed conditional crossing-level curve summarizing typical values at the moment of transition. A Monte Carlo study demonstrates that the proposed estimator accurately recovers a variety of smooth threshold shapes under different sample sizes and noise levels, with improved performance as crossing information increases. An illustrative application to country-level age-standardized colon cancer incidence trajectories demonstrates how the framework yields stable empirical boundary reconstructions for male and female series, while explicitly accounting for left-censoring induced by the limited observation window.

Indexed as

Colonic NeoplasmsAlgorithmsFemaleHumansMonte Carlo Method

Identifiers

PMID42133645
PMCPMC13175388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.