ArticleBrain and behavior2026
Hypoplastic Vertebral Artery Contributes to Stroke by Promoting Progression of Basilar Artery Bending.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Vertebral Artery Hypoplasia and Posterior Circulation Vulnerability: A Systematic Review of Epidemiological, Hemodynamic, and Clinical Evidence.Neurology international · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundAs a well-recognized vascular variation, hypoplastic vertebral artery has been recognized as a potential risk for stroke. We aimed to assess the odds of new-onset stroke over a 20-year period in subjects with versus without hypoplastic vertebral artery, exploring how the progression of basilar artery bending mediates the odds.
methodsThis was a retrospective cohort study, with 20 years of follow-up (2004-2024, analysis performed in June 2025). The primary outcome was the occurrence of new-onset posterior circulation infarction during follow-up. Logistic regression models were fitted for new-onset posterior circulation infarction as gender, baseline stroke, baseline posterior circulation infarction, basilar artery stenosis during follow-up, the progression of basilar artery bending, and hypoplastic vertebral artery. Mediation analyses were conducted for vertebral artery stenosis during follow-up, basilar artery stenosis during follow-up, and the progression of basilar artery bending.
resultsA total of 1464 subjects were included, 547 with hypoplastic vertebral artery. During the 20-year follow-up, 91 participants had new-onset posterior circulation infarction. The occurrence of new-onset posterior circulation infarction was significantly associated with progression of basilar artery bending (odds ratio 1.700, 95% confidence interval 1.032-2.798, p = 0.037) and hypoplastic vertebral artery (odds ratio 1.481, 95% confidence interval 1.019-2.003, p = 0.015). The proportion of new-onset posterior circulation infarction attributable to hypoplastic vertebral artery was mediated by the progression of basilar artery bending, accounting for approximately 50.2% (95% confidence interval 3.2%-102.4%).
conclusionsResults of this study revealed that hypoplastic vertebral artery was associated with new-onset posterior circulation infarction, and progression of basilar artery bending may serve as a potential intermediate factor in this association.
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