ArticleJournal of investigative medicine high impact case reports
Primary Lung Adenocarcinoma as a Second Neoplasm Following Chronic Lymphocytic Leukemia: A Case Report.
Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Chronic lymphocytic leukemia (CLL) and its variant, small lymphocytic lymphoma (SLL), are common adult leukemias characterized by the accumulation of mature monoclonal B lymphocytes. CLL primarily involves peripheral blood, spleen, and lymph nodes, whereas SLL predominantly affects lymph nodes. Patients with CLL/SLL are at increased risk of developing second primary malignancies, including lung cancer, highlighting the need for ongoing surveillance. We report the case of an 83-year-old man with a history of CLL/SLL who developed pulmonary adenocarcinoma. He presented weight loss and constitutional symptoms; imaging revealed retroperitoneal and mesenteric lymph node conglomerates along with a lung lesion. Histopathology confirmed SLL in the lymph nodes and primary mucinous adenocarcinoma of the lung. Evidence shows a heightened risk of second primary neoplasms in CLL/SLL, particularly among patients exposed to alkylating agents. This case emphasizes the role of demographic and treatment-related factors-such as male sex, advanced age, smoking history, and therapeutic regimens-in secondary cancer development. Vigilant monitoring and a multidisciplinary approach tailored to individual risk are essential for early detection and optimal management in this population.
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