Evidence map›Paper›PMID 42133263›Full record

ArticleMagma (New York, N.Y.)2026

Towards harmonized spectral quantification in MRSI: comparative analysis of backward-linear-predicted and original

Alessio Siviglia, Brayan Alves, Cristina Cudalbu, Bernard Lanz

Abstract read
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In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alessio SivigliaCIBM Center for Biomedical Imaging, Lausanne, Switzerland. alessio.siviglia@epfl.ch.ORCID http://orcid.org/0009-0003-4905-7577
Brayan AlvesCIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Cristina CudalbuCIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Bernard LanzCIBM Center for Biomedical Imaging, Lausanne, Switzerland. bernard.lanz@epfl.ch.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 201218Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 207935
6 · The paper itself

Abstract

objectiveWe hypothesized that the inherent acquisition delay (AD) in MATERIALS AND

methods2D

resultsIn vivo and simulated data showed clear AD-dependent variations for several metabolites (Gln, tCho, tNAA, Ins, Tau), with discrepancies frequently > 10% despite AD-specific basis sets. Simulations confirmed metabolite-specific biases increasing with AD. BLP reconstruction preserved quantification consistency up to ~ 0.98 ms of recovered FIDs, reducing inter-AD mismatches in vivo-particularly for Tau, tNAA and tCho-lowering the mean discrepancy from 10.5% to ~ 5%. DISCUSSION: This work supports BLP as a practical strategy to improve consistency and comparability in MRSI studies.

Indexed as

BrainMagnetic resonance spectroscopic imagingPreclinical metabolic mappingSpectral quantification

Identifiers

PMID42133263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.