ArticleJournal of assisted reproduction and genetics2026
TEX44 deficiency induces asthenoteratozoospermia by disrupting sperm axonemal integrity and mitochondrial sheath assembly, and ICSI enables successful fertility rescue.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAsthenoteratozoospermia represents a leading cause of idiopathic male infertility, characterized by diminished sperm motility and aberrant morphology. Testis-expressed protein 44 (Tex44) is essential for sperm flagellar development in mice, yet its pathogenic contribution to human asthenoteratozoospermia and clinical translational relevance remain largely undefined. This study aimed to characterize the role of TEX44 in sperm structure and function, identify pathogenic TEX44 variants in infertile men, and evaluate intracytoplasmic sperm injection (ICSI) as a fertility-rescue strategy.
methodsA Tex44-knockout (Tex44
resultsTex44
conclusionsTex44 deficiency causes asthenoteratozoospermia by impairing sperm axonemal integrity and mitochondrial sheath assembly. Pathogenic TEX44 variants are associated with human asthenoteratozoospermia, and ICSI serves as an effective therapeutic intervention for affected patients. These findings establish TEX44 as a novel diagnostic biomarker, broaden the genetic architecture of male infertility, and strengthen the translational bridge between basic science and clinical reproductive care.
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