Evidence map›Paper›PMID 42133215›Full record

ReviewMolecular biology reports2026

Benzodiazepines for anxiety and depression: an updated overview of current use and major outcomes.

Hanane El Fatimi, Hanane Khalki, Bilal El-Mansoury, Younes Zaid, Loubna Khalki

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanane El FatimiMohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.
Hanane KhalkiBiotechnological Laboratory and Development of Natural Resources (B2DRN), Polydisciplinary Faculty of Beni-Mellal, Sultan Moulay Slimane University, Mghila, Beni Mellal, Morocco.
Bilal El-MansouryLaboratory of Anthropology, Biotechnology and Health, Team Physiopathology Nutritional, Neurosciences and Toxicology, Faculty of Sciences, Chouaib Doukkali University, El Jadida, Morocco.
Younes ZaidDepartment of Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco.
Loubna KhalkiMohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco. lkhalki@um6ss.ma.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety and depressive disorders are serious, debilitating health problems that negatively impact the patient's overall well-being and life satisfaction. The prevalence of these mood disorders has increased recently. Several treatment approaches against anxiety and depressive disorders are now available. For instance, pharmacological treatments, including the use of benzodiazepines (BZDs), have been increasingly documented. The present paper gives an insight into the underlying mechanisms of BZD anxiolytic abilities and points out the paramount role of some brain regions and systems in mediating this anxiolytic effect, and these include the HPA axis, the amygdala, and the hippocampus. Additionally, it aims to list and understand the mechanisms of adverse effects associated with these medications, including dependence, memory impairment, and withdrawal-associated symptoms, opening new perspectives in the design and production of other safe and more options for efficient medications.

Indexed as

Anti-Anxiety AgentsAnxietyAnxiety DisordersBenzodiazepinesDepressionDepressive DisorderAnimalsHumansAnti-Anxiety AgentsBenzodiazepinesAnxietyBenzodiazepinesDepressionPharmacological treatment; Psychological well-beingSide effects

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.