ArticleInternational ophthalmology2026
Corneal epithelial mapping after accelerated corneal cross-linking: early remodeling patterns.
Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate early regional corneal epithelial thickness changes following accelerated epithelium-off corneal cross-linking (CXL) in progressive keratoconus using anterior segment optical coherence tomography (AS-OCT), and to explore their relationship with anterior corneal curvature and spherical equivalent.
designProspective case series.
methodsNinety eyes of 75 patients with progressive keratoconus underwent accelerated epithelium-off CXL (9 mW/cm
resultsBaseline central epithelial thickness was 59.7 ± 5.8 µm. At 1 month, central thickness showed minimal change, while at 3 months it increased to 62.9 ± 4.0 µm (P < 0.001). Sectoral analysis demonstrated relative thinning in nasal and inferonasal outer regions (1-3 µm; P < 0.05) and thickening in selected temporal sectors. The thinnest epithelial point shifted from the inferotemporal to the inferonasal regions. Kmax demonstrated a borderline postoperative change (P = 0.051), and no statistically significant correlations were observed between epithelial thickness changes and Kmax at any time point. Spherical equivalent remained unchanged (P = 0.19).
conclusionsAccelerated epithelium-off CXL was associated with early, region-specific changes in epithelial thickness within three months after surgery. Variability in measurements due to the tear film and the short follow-up period likely influences these results, reflecting early surface remodeling rather than permanent stromal stabilization. Epithelial mapping may provide additional structural information during early postoperative monitoring; however, its ability to predict long-term treatment outcomes requires further research.
Indexed as
Identifiers
42133149What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.