A wearable electrochemical sensor for sweat cortisol detection based on molecularly imprinted polymer nanoparticles and cellulose nanofiber/carbon nanotube conductive aerogel.

Zeyu Ming, Xiangchuan Zhao, Changshun Gu, Wenjing Qin, Zhangye Jiang, Xingyue Zhang, Yanli Wang, Shougen Yin

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Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Zeyu MingSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Xiangchuan ZhaoSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Changshun GuSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Wenjing QinSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Zhangye JiangSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Xingyue ZhangSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China.

Yanli WangTianjin Key Laboratory of Quantum Optics and Intelligent Photonics, School of Science, Tianjin University of Technology, Tianjin, 300384, China.

Shougen YinSchool of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China. sgyin@tjut.edu.cn.

Funding

Tianjin Key Discipline of Material Physics and Chemistry and Scientific Developing Foundation of Tianjin Education Commission 2018ZD09

6 · The paper itself

Abstract

Sensitive, non-invasive detection of the steroid hormone cortisol aids in preventing chronic diseases such as depression and anxiety caused by stress. This study presents the development of a novel sweat cortisol sensor, integrating core-shell structured molecularly imprinted polymer (MIP) nanoparticles with a three-dimensional conductive aerogel to enable efficient, non-invasive monitoring of stress-related cortisol levels. This sensor leverages the large specific surface area and conductive network of aerogel to enhance electron transport efficiency and sensor sensitivity. The MIP nanoparticles are engineered with a gold nanoparticle-modified Prussian blue analogue core, providing stable redox activity and optimizing electrochemical performance. The sensor exhibits an extensive detection range from 10 pM to 100 µM and a remarkably low detection limit of 4.36 × 10

Indexed as

Electrochemical TechniquesHydrocortisoneMolecularly Imprinted PolymersNanofibersNanoparticlesNanotubes, CarbonSweatWearable Electronic DevicesAerogelsBiosensing TechniquesCelluloseFerrocyanidesGoldHumansLimit of DetectionMetal NanoparticlesAerogelsCelluloseFerrocyanidesGoldHydrocortisoneMolecularly Imprinted PolymersNanotubes, CarbonAerogelCortisolMolecularly imprinted polymer; Screen printing; Electrochemical detection; Cyclic voltammetryNanoparticles

Identifiers

PMID42133086

DOI10.1007/s00604-026-08106-3

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.