Evidence map›Paper›PMID 42132982›Full record

ReviewReproduction in domestic animals = Zuchthygiene2026

Advances in the Use of Recombinant Gonadotropins for Reproductive Biotechnologies in Ruminants: A Review.

Vitória Leite Di Domenico, Fabiane Pereira de Moraes, Natália Ávila de Castro, Fernando Caetano de Oliveira, Diogo Magnabosco, Bernardo Garziera Gasperin

Abstract readReview
In one paragraph

Review in Reproduction in domestic animals = Zuchthygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vitória Leite Di DomenicoPrograma de Pós-Graduação em Zootecnia, UFRGS, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-5822-7641
Fabiane Pereira de MoraesPrograma de Pós-Graduação em Veterinária, UFPel, Pelotas, Brazil.ORCID https://orcid.org/0000-0003-2502-4108
Natália Ávila de CastroPrograma de Pós-Graduação em Veterinária, UFPel, Pelotas, Brazil.ORCID https://orcid.org/0000-0002-7710-6044
Fernando Caetano de OliveiraFaculdade de Veterinária, UFRGS, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-5191-9901
Diogo MagnaboscoPrograma de Pós-Graduação em Zootecnia, UFRGS, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-8248-1076
Bernardo Garziera GasperinPrograma de Pós-Graduação em Zootecnia, UFRGS, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-3715-2345

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 406866/2022-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 22/2551-0000391-5
6 · The paper itself

Abstract

Recombinant gonadotropins, particularly recombinant follicle-stimulating hormone (rFSH) and recombinant equine chorionic gonadotropin (reCG), have emerged as viable alternatives to traditional animal-derived hormones in reproductive biotechnologies. This review aims to provide an updated and comprehensive overview of recombinant gonadotropins, with emphasis on the most recent scientific and technological advances in production and their application. This research integrates studies published following the recent commercial introduction of these molecules and incorporates findings generated by our research group. A total of 12 field studies in ruminants met the inclusion criteria, comprising four evaluating rFSH for superovulation and eight assessing reCG across different reproductive applications. Recent studies demonstrate that rFSH achieves similar superovulatory outcomes to conventional protocols, while reCG effectively promotes follicular growth, ovulation, and fertility in cattle and sheep, with results comparable to purified eCG. Beyond reproductive efficacy, recombinant hormones offer advantages such as reduced animal use, consistent product quality, and simplified management. These findings highlight recombinant gonadotropins as promising, ethical, and efficient tools for advancing assisted reproduction in ruminants.

Indexed as

Follicle Stimulating HormoneGonadotropinsReproductive Techniques, AssistedRuminantsAnimalsCattleChorionic GonadotropinFemaleGonadotropins, EquineRecombinant ProteinsSheepSuperovulationChorionic GonadotropinFollicle Stimulating HormoneGonadotropinsGonadotropins, EquineRecombinant Proteinsanimal welfarereproductive biotechnologytimed artificial insemination

Identifiers

PMID42132982
PMCPMC13175135

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.