ArticleInternational orthopaedics2026
Association of oxidized regenerated cellulose powder and tranexamic acid during total knee arthroplasty: clinical outcomes.
Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Japanese Orthopaedic Association and Societe Internationale de Chirugie Orthopedique et Tramatologie: Celebrating one hundred years of friendship and scientific exchange.International orthopaedics · 2026Article
- A brief story of Japanese orthopaedics: from the ancestral origins in Kyushu and Nara to the foundation of the Japanese orthopedic association in Tokyo.International orthopaedics · 2026Article
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Authors and funding
3 authors.
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Abstract
purposeThis study aimed to evaluate the association of oxidized regenerated cellulose (ORC) powder in perioperative blood management during total knee arthroplasty (TKA) using a subvastus approach with limited tourniquet use.
methodsWe retrospectively analyzed 140 patients who underwent primary TKA using the subvastus approach at our institution between January 2023 and December 2025. The Patients were divided into ORC (n = 69) and non-ORC (n = 71) groups based on the intraoperative application of ORC powder. All patients received local tranexamic acid (TXA), and the tourniquets were inflated only during cementation. To account for potential confounding, multivariable linear regression analysis was performed. The primary outcomes were estimated total blood loss (eTBL) and hidden blood loss (HBL). Secondary outcomes included postoperative pain (numeric rating scale, NRS) and the incidence of postoperative complications.
resultsThe ORC group demonstrated significantly lower eTBL (599.2 ± 211.9 vs. 713.4 ± 273.3 mL, p = 0.007) and HBL (398.3 ± 207.6 vs. 485.8 ± 273.0 mL, p = 0.03) compared to the non-ORC group. Multivariable analysis confirmed that ORC use was independently associated with lower eTBL (β = -117.2; p = 0.009) and HBL (p = 0.02), though it was not an independent predictor for pain reduction on postoperative day seven (p = 0.15). There were no significant differences in operative time, or the incidence of postoperative complications.
conclusionThe adjunctive use of ORC powder during TKA was associated with lower eTBL and HBL.
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