Evidence map›Paper›PMID 42132839›Full record

ReviewChemical Society reviews2026

How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.

Douglas B Kell, Ivayla Roberts

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Douglas B KellDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown St, Liverpool L69 7ZB, UK. dbk@liv.ac.uk.ORCID http://orcid.org/0000-0001-5838-7963
Ivayla RobertsDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown St, Liverpool L69 7ZB, UK. dbk@liv.ac.uk.ORCID http://orcid.org/0000-0003-3525-9787

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of possible variants representing the landscape of a protein sequence of length

Indexed as

Directed Molecular EvolutionProteinsBiocatalysisCatalysisEvolution, MolecularProteins

Identifiers

PMID42132839
PMCPMC13170745

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.