ArticleJACC. Advances2026
Adverse Pregnancy Outcomes and Prevalent Cardiovascular Disease Among an Urban Cohort in Haiti.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdverse pregnancy outcomes (APOs) have been linked with cardiovascular diseases (CVDs) in high-income countries, but evidence from low-income countries like Haiti is limited.
objectivesThe authors investigated the cross-sectional association between APO and prevalent CVD using the Haiti CVD Cohort.
methodsThis analysis included all female participants who completed a reproductive health questionnaire at their annual visit, which captured detailed pregnancy history. We analyzed the relationship between APO and prevalent CVD (defined as heart failure, myocardial infarction, or stroke, as a composite outcome and separately) on enrollment using Poisson regression models, adjusted for traditional risk factors.
resultsThis analysis included 1,146 women with a median age of 44 years (IQR: 31-55 years). Most participants lived in severe poverty, with 68.0% reporting income <1 USD/day, 67.0% reporting unemployment, and 46.0% reporting only primary education or less. APO were common, with 61.7% (n = 623) experiencing at least 1 APO. APO were significantly associated with heart failure in both age-adjusted (prevalence ratio [PR]: 1.54; 95% CI: 1.11-2.12) and fully adjusted models (PR: 1.44; 95% CI: 1.04-1.99). APOs were not significantly associated with prevalent stroke (PR: 1.05; 95% CI: 0.52-2.11). In the fully adjusted model, grand multiparity (5+ live births, reported by 20% [n = 230]) was associated with both CVD (PR: 1.54; 95% CI: 1.14-2.07) and heart failure (PR: 1.62; 95% CI: 1.17-2.24).
conclusionsCVD was more common in women with a history of APO or grand multiparity, driven primarily by high heart failure prevalence in this relatively young sample of women living in urban Haiti.
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