ReviewEpilepsia open2026
Ketogenic diet therapy for children with super-refractory status epilepticus in intensive care: International clinical practice recommendations.
Review in Epilepsia open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
objectiveWe aimed to create practical recommendations to support healthcare teams starting ketogenic diet therapy (KDT) for children with super-refractory status epilepticus in intensive care settings.
methodsA literature review was conducted to extract published data on patient selection, diet prescription, diet initiation, monitoring, fine-tuning, and discontinuation of KDT for super-refractory status epilepticus. Statements were formulated within each subtopic, and an online survey was distributed to gauge the extent of international agreement with these statements to inform consensus-based recommendations for initiation and maintenance of KDT in pediatric intensive care settings, with a focus on enteral nutrition. Consensus on a statement for inclusion in the core recommendations was reached if ≥75% of respondents "Agreed" or "Strongly Agreed". Recommendations from relevant published guidelines or studies were also included.
resultsTwenty-two relevant manuscripts were identified, and 25 statements were formulated. Seventy-two healthcare professionals responded to the survey, including dietitians, medics, nurses, intensivists, and a neurophysiologist. Clinical recommendations were made across the following areas, using evidence from published literature, survey agreement, or the clinical expertise of the authors: patient selection and timing of start, preparation for treatment, dietary prescription, diet initiation, monitoring adverse effects, fine tuning, and weaning of KDT. Thirty statements met the criteria for core recommendations. SIGNIFICANCE: These are the first international multidisciplinary recommendations for use of KDT for children with super-refractory status epilepticus, intended as a sensical guide for dietitians, neurologists, intensivists, and associated healthcare professionals. The majority of the recommendations are based on survey agreement due to a paucity of published evidence. PLAIN LANGUAGE SUMMARY: Children with very severe seizures that do not stop despite medication often need care in intensive care units. This study brings together published evidence and international expert consensus to provide clear guidance on when and how a high-fat, low-carbohydrate ketogenic diet can be started safely in this setting. The recommendations highlight early diet initiation, close monitoring, and strong teamwork between doctors, dietitians, nurses, and pharmacists while recognizing that more high-quality research is still needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.