Evidence map›Paper›PMID 42132613›Full record

ReviewNatural product reports2026

Structural determination of natural products at speeds and scale of high-throughput screening.

Christopher C Thornburg, Rohitesh Kumar, Dongdong Wang, Barry R O'Keefe, Tanja Grkovic

Abstract readReview
In one paragraph

Review in Natural product reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher C ThornburgNatural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, USA.ORCID http://orcid.org/0000-0002-4657-6895
Rohitesh KumarNatural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, USA.ORCID http://orcid.org/0000-0002-7187-937X
Dongdong WangNatural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, USA.ORCID http://orcid.org/0000-0002-7824-2507
Barry R O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702-1201, USA. okefeba@mail.nih.gov.ORCID http://orcid.org/0000-0003-0772-4856
Tanja GrkovicMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702-1201, USA. okefeba@mail.nih.gov.ORCID http://orcid.org/0000-0002-6537-3997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Covering 2000 up to 2025.This review assesses analytical techniques available for routine structural elucidation of small molecules as part of high-throughput screening campaigns of natural product libraries. The emphasis is on the speed and scale of task management and highlights advances in technologies and library tools that enable the structural elucidation of complex molecules on small-scale and rapid timelines. We present the state of the art in the natural product field and provide a critical assessment of available techniques and tools, with a focus on the ability to analyze large numbers of samples in short timelines that can meet the speed and scale of high-throughput screening.

Identifiers

PMID42132613
PMCPMC13159620

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.