ArticleClinical science (London, England : 1979)2026
The metabolic effects of post-sepsis feeding of meals with only essential amino acids.
Article in Clinical science (London, England : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nutritional support is a vital component of the rehabilitation process following sepsis. Essential amino acids (EAA) are recognized as a critical component for stimulating anabolism. However, it remains unclear whether EAA supplementation alone is more effective than providing a complete profile of total amino acids (TAA). We studied amino acid (AA) metabolism in 51 catheterized pigs (±27 kg) using the pulse tracer approach over a 7-day recovery period following sepsis. Animals were randomly and blindly assigned to receive post-sepsis nutrition containing either an EAA or a TAA mixture based on the composition of pig muscle. Statistical analyses were performed using a generalized linear mixed model. Plasma concentrations of EAA increased substantially in the EAA group post-sepsis (interaction effect, P<0.001), while those of non-essential AA increased in both groups (time effect, P<0.001). Whole-body intracellular production of most AA was reduced on day 3 and remained low on day 7 post-sepsis, with only small differences observed between the two groups. On day 7 post-sepsis, pigs receiving only EAA showed significantly (all P<0.001) lower intracellular production of hydroxyproline (-36%), ornithine (-11%), and tryptophan (-20%) and higher production of arginine (66%), citrulline (18%), glutamine (18%), taurine (22%), and some EAA. The EAA group showed a significantly higher net protein breakdown post-sepsis. In this sepsis-recovery pig model, dietary supplementation of both EAA and TAA failed to normalize the intracellular production of AA. More importantly, providing only EAA resulted in a significantly greater net protein breakdown compared with the TAA group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.