Evidence map›Paper›PMID 42132469›Full record

ArticleEuropean stroke journal2026

Lumbar drainage in intracerebral haemorrhage with intraventricular haemorrhage (DRAIN IVH): protocol for a multi-centre, randomised-controlled, two-arm, assessor-blinded trial.

Min Chen, Lukas D Sauer, Christian Herweh, Anja Sander, Christina Klose, Wolfgang Wick, Stefan Wolf, Silvia Schönenberger

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06510842 (Lumbar Drainage of Intraventricular Hemorrhage The DRAIN IVH Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06510842 narecruitingnot on this map

Lumbar Drainage of Intraventricular Hemorrhage The DRAIN IVH Randomized Controlled Trial

TypeinterventionalSponsorUniversity Hospital HeidelbergRan2025 to 2029Enrolled354ConditionsIntraventricular Hemorrhage, Lumbar Drainage, External Ventricular DrainageArmsExternal drainage of intraventricular hemorrhage
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Min ChenDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-9079-9298
Lukas D SauerInstitute of Medical Biometry, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-1340-9994
Christian HerwehDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Anja SanderInstitute of Medical Biometry, Heidelberg University, Heidelberg, Germany.
Christina KloseInstitute of Medical Biometry, Heidelberg University, Heidelberg, Germany.
Wolfgang WickDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-6171-634X
Stefan WolfDepartment of Neurosurgery, Charité - Berlin University Medicine, Berlin, Germany.
Silvia SchönenbergerDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-3348-6719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracerebral haemorrhage with ventricular extension is associated with poor neurological outcome and high mortality. External ventricular drainage (EVD) is a standard intervention for acute hydrocephalus in such patients, yet the role of an additional early lumbar drainage (LD) remains uncertain.

aimTo evaluate whether early LD leads to improved functional outcomes in patients suffering from ICH with intraventricular haemorrhage (IVH) who require an EVD, compared to patients not receiving early LD. STUDY

designDRAIN IVH is a multi-centre, parallel-group, open-label randomised controlled trial with blinded endpoint evaluation. Key inclusion criteria are ICH with IVH in the third and/or fourth ventricle with the need for EVD placement due to acute hydrocephalus, age ≥ 18 years and LD insertion within 72 h after symptom onset or last-seen-well. SAMPLE SIZE: A total of 354 patients will be randomised for either early LD plus standard of care (comprising EVD) or standard of care alone. STUDY ENDPOINTS: The primary outcome is the rate of modified Rankin Scale score 0-3 at 180 days. Secondary outcomes include need for VP shunt, need for tracheostomy and EQ-5D. Safety outcomes include mortality, bacterial ventriculitis/meningitis, EVD complications and LD complications. SUMMARY: DRAIN IVH will provide evidence for physicians whether early LD in addition to standard of care treatment leads to better outcomes in ICH with IVH compared to standard of care alone.

trial registrationClinicaltrials.gov; NCT06510842.

Indexed as

Cerebral HemorrhageCerebral Intraventricular HemorrhageDrainageHydrocephalusCerebral VentriclesFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment Outcomeintracerebral haemorrhageintraventricular haemorrhagelumbar drainage

Identifiers

PMID42132469
PMCPMC13173431

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.