SynthesisVeterinary medicine and science2026
META-Analysis of the Relationship Between c.282C>G Polymorphism of the CAST Gene and Meat Quality Traits of Cattle.
Synthesis in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe quality of meat is influenced by both genetic factors and environmental influences. The c.282C>G polymorphism of the CAST gene is a substitution of cytosine with guanine (C/G) deployed in intron five and exhibited an essential effect on meat tenderness, cook loss and meat colour. The effect of the CAST gene on meat quality parameters has been studied extensively in several cattle breeds. However, the results are inconsistent. To solve the unclearness because of variation, large sample sizes or meta-analyses were required.
objectivesThe aim of the study was to evaluate the genotypes and alleles of the c.282C>G polymorphism of the CAST gene in cattle and to investigate its relationship with some meat quality traits.
methodsFor this purpose, the genotype and allele frequencies of 22 studies were determined and combined with meta-analysis. In addition, meta-analyses were applied for studies reporting tenderness, redness, yellowness, lightness and cook loss parameters. Heterogeneity was examined using the Cochran Q test, and publication bias was analysed using the Begg and Mazumdar test. RESULTS AND
conclusionsAs a result of the meta-analysis, the combined ratios of CC, GC and GG genotypes were estimated as 0.430 (Cochran Q = 110.710; p < 0.001), 0.440 (Cochran Q = 59.950; p < 0.001) and 0.130 (Cochran Q = 67.620; p < 0.001) with random effects model. The combined ratios of C and G alleles were 0.648 and 0.352 (Cochran Q = 240.620; p < 0.001). The highest combined ratios were obtained for GC genotype and C allele. According to the results, a consensus was reached that there is a significant relationship between meat quality and the CAST gene c.282C>G polymorphism. The current study may provide crucial information on improving meat quality in cattle breeding.
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