Evidence map›Paper›PMID 42132331›Full record

ArticleMolecular pain

Metformin exhibits analgesic activity in neuronal cell models and CFA-induced inflammatory pain in mice.

Thi-Chau-Loan Phan, Jui-Ting Chang, Chih-Hsiang Ma, Yao-Jen Liang

Abstract read
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In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thi-Chau-Loan PhanGraduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan.
Jui-Ting ChangSchool of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Chih-Hsiang MaGraduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan.
Yao-Jen LiangGraduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan.ORCID 0000-0002-0816-9279

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory pain is mediated by complex interactions between immune signaling and sensory neurons, with prostaglandin E2-dependent pathways playing a central role in nociceptive sensitization. Metformin, a first-line antidiabetic drug, has emerged as a potential non-opioid analgesic due to its pleiotropic anti-inflammatory and neuroprotective properties. In this study, we investigated the analgesic effects of metformin using both an in vitro neuronal sensitization model and an in vivo model of inflammatory pain. In SH-SY5Y neuronal cells, PGE2 exposure significantly reduced Na

Indexed as

AnalgesicsInflammationMetforminNeuronsPainAnimalsCell Line, TumorCyclic AMPDinoprostoneDisease Models, AnimalFreund's AdjuvantHumansMaleMiceNAV1.7 Voltage-Gated Sodium ChannelSodium-Potassium-Exchanging ATPaseAnalgesicsCyclic AMPDinoprostoneFreund's AdjuvantMetforminNAV1.7 Voltage-Gated Sodium ChannelSodium-Potassium-Exchanging ATPaseTRPV Cation Channelsinflammatory painMetforminNa+/K+-ATPaseNaV1.7non-opioid analgesicTRPV1

Identifiers

PMID42132331
PMCPMC13305277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.