Evidence map›Paper›PMID 42132245›Full record

ArticleAnnals of medicine2026

MNS induces antiviral protection and suppresses inflammation.

Yang Zhao, Xingyu Chen, Yunfei Xie, Hanjie Liu, Boming Kang, Shuailong Zheng, Yuxiang Ren, Qian Wang, Fuping You, Haoxiang Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang ZhaoDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.ORCID 0009-0002-1282-8975
Xingyu ChenDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.
Yunfei XieDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.
Hanjie LiuSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Boming KangDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.
Shuailong ZhengKey Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, China.
Yuxiang RenDepartment of Chemistry, Tsinghua University, Beijing, China.
Qian WangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Fuping YouDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.
Haoxiang QiDepartment of Microbiology & Infectious Disease Center, Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, NHC Key Laboratory of Medical Immunology, School of Basic Medical Science Peking University, Peking University Health Science Center, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying safe and broad-spectrum antiviral and anti-inflammatory agents remains an urgent need in infectious and inflammatory diseases. Here, we demonstrated that MNS (NSC170724), a small-molecule nitrovinyl benzodioxole, enhanced antiviral defense while limiting excessive inflammation.

methodsThe antiviral activity of MNS was evaluated in multiple cell lines and mouse infection models across DNA and RNA viruses. Virus-induced and LPS-induced inflammatory responses were assessed using RT-qPCR, ELISA and western blotting. Bulk RNA-seq and ATAC-seq were performed to define transcriptional and epigenetic mechanisms.

resultsMNS significantly suppressed viral infection

conclusionsWith potent activity against viral replication and inflammation in cellular and animal models, MNS emerges as a promising candidate for the treatment of viral infections and hyperinflammatory conditions.

Indexed as

Anti-Inflammatory AgentsAntiviral AgentsInflammationVirus DiseasesAnimalsCytokinesDisease Models, AnimalHumansLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLViral LoadAnti-Inflammatory AgentsAntiviral AgentsCytokinesLipopolysaccharidesbroad-spectrum antiviralepigenetic reprogrammingMNS (NSC170724), host-directed therapy

Identifiers

PMID42132245
PMCPMC13178039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.