Evidence map›Paper›PMID 42132197›Full record

Observational studyJournal of the American Heart Association2026

Primary Results of the SALAMANDER Registry: A Multicenter Observational Cohort Study.

Wojciech Wańha, Łukasz Kuźma, Mariusz Kowalewski, Sylwia Iwańczyk, Joanna Grygier, Jan Jeske, Marco Frazzetto, Radosław Litwinowicz, Marian Burysz, Ewa Gaszewska-Żurek and 50 more

Registry-linked trialAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05144958 (Stand-Alone Left Atrial Appendage Occlusion for throMboembolism Prevention in Nonvalvular Atrial fibrillatioN DiseasE Registry), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05144958 unknown statusnot on this map

Stand-Alone Left Atrial Appendage Occlusion for throMboembolism Prevention in Nonvalvular Atrial fibrillatioN DiseasE Registry (SALAMANDER)

Typeobservational_patient_registrySponsorNicolaus Copernicus UniversityRan2019 to 2025Enrolled400ConditionsAtrial Fibrillation, StrokeArmsTotally thoracoscopic LAAO - ATRICLIP, Percutaneous LAAO - WATCHMAN, Hybrid- minimally invasive LAAO - LARIAT
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors.

Wojciech WańhaDepartment of Cardiology and Structural Heart Diseases Medical University of Silesia Katowice Poland.ORCID 0000-0003-1220-9496
Łukasz KuźmaDepartment of Cardiac Surgery and Transplantology National Medical Institute of the Ministry of the Interior and Administration Warsaw Poland.ORCID 0000-0002-4156-5695
Mariusz KowalewskiDepartment of Cardiac Surgery and Transplantology National Medical Institute of the Ministry of the Interior and Administration Warsaw Poland.ORCID 0000-0002-5478-3245
Sylwia IwańczykDCB Academy Milan Italy.ORCID 0000-0003-0509-6075
Joanna GrygierFirst Department of Cardiology Poznan University of Medical Sciences Poznań Poland.ORCID 0009-0003-9660-1934
Jan JeskeFirst Department of Cardiology Poznan University of Medical Sciences Poznań Poland.ORCID 0000-0003-4775-2157
Marco FrazzettoDCB Academy Milan Italy.ORCID 0000-0002-6543-7567
Radosław LitwinowiczDepartment of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College St. John Paul II Hospital Krakow Poland.ORCID 0000-0003-3736-8987
Marian BuryszDepartment of Cardiac Surgery Regional Specialist Hospital Grudziądz Poland.
Ewa Gaszewska-ŻurekDepartment of Cardiology and Structural Heart Diseases Medical University of Silesia Katowice Poland.
Claudio SanfilippoDivision of Cardiology Centro Cuore Morgagni Catania Italy.ORCID 0000-0002-1508-4927
Tomasz BochenekFirst Department of Cardiology Medical University of Silesia Katowice Poland.ORCID 0000-0002-1065-2665
Michał LelekFirst Department of Cardiology Medical University of Silesia Katowice Poland.
Krystian WitaFirst Department of Cardiology Medical University of Silesia Katowice Poland.
Zenon HuczekFirst Department of Cardiology Medical University of Warsaw Poland.ORCID 0000-0002-5912-2649
Agnieszka Kapłon-CieślickaFirst Department of Cardiology Medical University of Warsaw Poland.ORCID 0000-0003-2020-3027
Tomasz MazurekFirst Department of Cardiology Medical University of Warsaw Poland.ORCID 0000-0002-3693-8741
Piotr ScisłoFirst Department of Cardiology Medical University of Warsaw Poland.
Jerzy SachaDepartment of Cardiology, University Hospital in Opole, Opole, Poland; Faculty of Physical Education and Physiotherapy Opole University of Technology Opole Poland.ORCID 0000-0001-7504-7506
Krzysztof StruniawskiDepartment of Invasive Cardiology Medical University of Bialystok Poland.
Brunon TomasiewiczDepartment of Heart Diseases Wroclaw Medical University Wroclaw Poland.ORCID 0000-0003-3291-3560
Facehauwe MezqueDepartment of Heart Diseases Wroclaw Medical University Wroclaw Poland.ORCID 0009-0003-7617-0268
Wiktor KuliczkowskiDepartment of Heart Diseases Wroclaw Medical University Wroclaw Poland.
Krzysztof BartuśDepartment of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College St. John Paul II Hospital Krakow Poland.ORCID 0000-0002-3457-6978
Sławomir DobrzyckiDepartment of Invasive Cardiology Medical University of Bialystok Poland.ORCID 0000-0003-0599-7017
Michał ŚwięczkowskiDepartment of Invasive Cardiology Medical University of Bialystok Poland.ORCID 0000-0002-7381-6604
Anna KuraszDepartment of Invasive Cardiology Medical University of Bialystok Poland.ORCID 0000-0003-0526-3339
Paweł KraliszDepartment of Invasive Cardiology Medical University of Bialystok Poland.ORCID 0000-0002-6757-2228
Dawid MiśkowiecDepartment of Cardiology Medical University of Lodz Poland.ORCID 0000-0001-8327-9550
Jarosław D KasprzakDepartment of Cardiology Medical University of Lodz Poland.ORCID 0000-0002-5850-8187
Marta ChameraDepartment of Cardiology and Structural Heart Diseases Medical University of Silesia Katowice Poland.ORCID 0009-0006-7462-2656
Maksymilian MielczarekFirst Department of Cardiology Medical University of Gdansk Poland.ORCID 0000-0001-5870-1166
Piotr DrewlaFirst Department of Cardiology Medical University of Gdansk Poland.
Rafał GałąskaFirst Department of Cardiology Medical University of Gdansk Poland.ORCID 0000-0001-9487-2966
Fabrizio UgoDivision of Interventional Cardiology Sant'Andrea Hospital Vercelli Italy.ORCID 0000-0002-0504-2715
Marco FranzinoDivision of Interventional Cardiology Sant'Andrea Hospital Vercelli Italy.ORCID 0009-0008-1702-6908
Bernardo CorteseDCB Academy Milan Italy.ORCID 0000-0002-5808-7810
Filippo L GurgoglioneDCB Academy Milan Italy.
Luigi VignaliDivision of Cardiology Parma University Hospital Parma Italy.
Giorgio BenattiDivision of Cardiology Parma University Hospital Parma Italy.ORCID 0000-0002-3695-0409
Federico BarocelliDivision of Cardiology Parma University Hospital Parma Italy.ORCID 0000-0002-1412-4747
Piotr WacińskiClinical Department of Interventional Cardiology Medical University of Lublin Poland.ORCID 0000-0002-8537-8867
Piotr NiezgodaDepartment of Cardiology and Internal Medicine Collegium Medicum, Nicolaus Copernicus University Bydgoszcz Poland.ORCID 0000-0002-9912-9730
Adam SukiennikDepartment of Cardiology and Internal Medicine Collegium Medicum, Nicolaus Copernicus University Bydgoszcz Poland.ORCID 0000-0003-1044-218X
Jacek KubicaDepartment of Cardiology and Internal Medicine Collegium Medicum, Nicolaus Copernicus University Bydgoszcz Poland.ORCID 0000-0001-8250-754X
Mario IannaconeU.O. Cardiologia Interventistica, Ospedale San Giovanni Bosco, ASL Città di Torino Torino Italy.ORCID 0000-0003-0571-3918
Klaudia KowalskaKashubian Center for Heart and Vascular Diseases Wejherowo Poland.
Łukasz LewickiFirst Department of Cardiology Medical University of Gdansk Poland.ORCID 0000-0002-7310-8480
Carmelo GrassoDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico - San Marco" University of Catania Italy.ORCID 0009-0006-2463-3963
Davide CapodannoDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico - San Marco" University of Catania Italy.ORCID 0000-0002-5156-7723
Fabrizio D'AscenzoDivision of Cardiology, Cardiovascular and Thoracic Department A.O.U. Città della Salute e della Scienza Turin Italy.ORCID 0000-0002-6646-9317
Ovidio de FilippoDivision of Cardiology, Cardiovascular and Thoracic Department A.O.U. Città della Salute e della Scienza Turin Italy.ORCID 0000-0002-4915-9501
Francesco BrunoDivision of Cardiology, Cardiovascular and Thoracic Department A.O.U. Città della Salute e della Scienza Turin Italy.ORCID 0000-0003-0019-0273
Radosław GocołDepartment of Cardiac Surgery, Upper-Silesian Medical Centre Medical University of Silesia Katowice Poland.
Zbigniew KalarusDepartment of Cardiology, DMS in Zabrze Medical University of Silesia Katowice Poland.ORCID 0000-0003-3921-7234
Piotr SuwalskiDepartment of Cardiac Surgery and Transplantology National Medical Institute of the Ministry of the Interior and Administration Warsaw Poland.ORCID 0000-0003-2670-4164
Marek GrygierFirst Department of Cardiology Poznan University of Medical Sciences Poznań Poland.ORCID 0000-0002-1134-7099
Grzegorz SmolkaDepartment of Cardiology, School of Health Sciences (SHS) Medical University of Silesia Katowice Poland.ORCID 0000-0003-2031-822X
Gregory Y H LipLiverpool Centre for Cardiovascular Science, University of Liverpool Liverpool John Moores University and Liverpool Heart and Chest Hospital Liverpool UK.ORCID 0000-0002-7566-1626
Wojciech WojakowskiDepartment of Cardiology and Structural Heart Diseases Medical University of Silesia Katowice Poland.ORCID 0000-0002-3681-5207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe balance between thromboembolic complications and bleeding risk in anticoagulated patients with atrial fibrillation remains challenging, with left atrial appendage occlusion (LAAO) representing a potential alternative. Our prospective multicenter study aimed to evaluate the feasibility, safety, technical, and procedural outcomes of the contemporary practice of stand-alone LAAO.

methodsThe SALAMANDER (Stand-Alone Left Atrial Appendage Occlusion for Thromboembolism Prevention in Nonvalvular Atrial Fibrillation Disease) registry is a real-world, multicenter, observational cohort study conducted at 16 cardiac centers in Europe between 2010 and 2024, evaluating the safety and efficacy of LAAO using contemporary devices.

resultsA total of 1660 patients were enrolled, with a median age of 76 (interquartile range, 70-81) years and 38% being women. The median CHA

conclusionsIn this large prospective cohort, technical and procedural success rates were similar across all LAAO devices, suggesting comparable safety and efficacy. Postprocedural therapy typically involves dual antiplatelet therapy, with all patients requiring some pharmacological treatment. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05144958.

Indexed as

Atrial FibrillationLeft Atrial Appendage ClosureThromboembolismAgedAged, 80 and overAnticoagulantsEuropeFemaleHemorrhageHumansMalePlatelet Aggregation InhibitorsProspective StudiesRegistriesRisk FactorsTreatment OutcomeAnticoagulantsPlatelet Aggregation Inhibitorsantithrombotic regimenleft atrial appendage occlusionprocedural successtechnical success

Identifiers

PMID42132197
PMCPMC13279340

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.