Evidence map›Paper›PMID 42132077›Full record

ReviewChemistry & biodiversity2026

Evaluation of Polysaccharides Safety and Potential Bioactivities Using Zebrafish: A Review.

Qizhong Lian, Yiming Wang, Fei Wang, Xianghe Meng, Ziyoviddin Yusupov, Komiljon Tojibaev, Zhenghai Zhang, Mengmeng Sun, Min He

Abstract readReview
In one paragraph

Review in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qizhong LianChangchun University of Chinese Medicine, Changchun, China.
Yiming WangChangchun University of Chinese Medicine, Changchun, China.
Fei WangThe Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Xianghe MengThe Jilin Province School-Enterprise Cooperation Technology Innovation Laboratory of Herbal Efficacy Evaluation Based on Zebrafish Model Organisms, Changchun University of Chinese Medicine, Changchun, China.
Ziyoviddin YusupovInstitute of Botany, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan.
Komiljon TojibaevInstitute of Botany, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan.
Zhenghai ZhangCollege of Chinese Materia Medica, Jilin Agricultural Science and Technology University, Jilin City, Jilin, China.
Mengmeng SunChangchun University of Chinese Medicine, Changchun, China.
Min HeChangchun University of Chinese Medicine, Changchun, China.ORCID https://orcid.org/0000-0001-6755-7872

Funding

Jilin Provincial Development and Reform Commission 2023C028-1Ministry of Human Resources and Social Security of the People's Republic of China High-Level Talent Project 030102070Ministry of Human Resources and Social Security of the People's Republic of China High-Level Talent Project 030102071Pilotscale Selection Project of Colleges and Universities in Changchun City 24GXYSZZ10
6 · The paper itself

Abstract

In recent years, polysaccharides, as a class of natural biopolymers mainly from plant/aquatic organism sources, have received increasing attention due to their diverse health benefits, thus with potential for nutraceutical and functional foods. At the same time, their safety has not yet been adequately addressed, yielding uncertainty regarding their quality and safety. As a vertebrate model, zebrafish are favored for their rapid development, high reproductive rate, transparency, and genetic tractability, which are extremely beneficial for safety evaluation and functional evaluation. In the zebrafish model, more and more polysaccharides derived from plant/aquatic food have shown significant functional potentials, such as melanin production, osteoporosis, obesity, etc., providing valuable insights into health benefits. This review aims to summarize functional and safety studies of polysaccharides from plant/aquatic organism sources based on the zebrafish model, and to promote their development into novel nutritional and functional foods. This could open exciting new avenues for food research, promising to reveal new functional applications and deepen our understanding of complex biological systems.

Indexed as

PolysaccharidesZebrafishAnimalsPolysaccharidesfood safetyfunctional foodpolysaccharideszebrafish

Identifiers

PMID42132077
PMCPMC13376699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.