Evidence map›Paper›PMID 42132002›Full record

ArticlePsychological medicine2026

The link between basic visual processing and higher-level social cognition: Eye gaze perception as a bridge in a transdiagnostic sample enriched with social dysfunction.

Kelly Mathis, Scott D Blain, Laura Locarno, Carly A Lasagna, Serena DeStefani, Jacob Kraft, Costanza Colombi, Katharine N Thakkar, Cynthia Z Burton, Ivy F Tso

Abstract read
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Kelly MathisDepartment of Psychiatry and Behavioral Health, https://ror.org/00rs6vg23The Ohio State University, Columbus, OH, United States.ORCID 0009-0005-7971-0113
Scott D BlainDepartment of Psychiatry and Behavioral Health, https://ror.org/00rs6vg23The Ohio State University, Columbus, OH, United States.ORCID 0000-0002-2751-3629
Laura LocarnoDepartment of Psychiatry and Behavioral Health, https://ror.org/00rs6vg23The Ohio State University, Columbus, OH, United States.ORCID 0009-0002-0864-0398
Carly A LasagnaDepartment of Psychology, https://ror.org/00jmfr291University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0003-3760-4505
Serena DeStefaniDepartment of Psychiatry and Behavioral Health, https://ror.org/00rs6vg23The Ohio State University, Columbus, OH, United States.ORCID 0000-0003-2289-7798
Jacob KraftDepartment of Psychology, https://ror.org/0043h8f16University of South Dakota, Vermillion, SD, United States.ORCID 0000-0001-9607-014X
Costanza Colombihttps://ror.org/02w8ez808IRCCS Stella Maris Foundation, 56128 Pisa, Italy.ORCID 0000-0002-3396-8822
Katharine N ThakkarDepartment of Psychology, https://ror.org/05hs6h993Michigan State University, East Lansing, MI, United States.ORCID 0000-0002-0026-2030
Cynthia Z BurtonDepartment of Psychology, https://ror.org/00jmfr291University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0002-9703-8106
Ivy F TsoDepartment of Psychiatry and Behavioral Health, https://ror.org/00rs6vg23The Ohio State University, Columbus, OH, United States.ORCID 0000-0002-0984-1186

Funding

Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigationR01MH122491 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2020 to 2024
$2.9M
National Science Foundation Graduate Research Fellowship Program DGE-1841052NIMH NIH HHS R01 MH122491NIMH NIH HHS R01MH122491
6 · The paper itself

Abstract

backgroundSocial cognitive deficits are common across many psychiatric conditions and contribute to broader social dysfunction. One hypothesized mechanism involves altered basic visual processing, which may disrupt the perception of low-level social cues and, in turn, compromise broader social cognitive processes. Here, we examined relations between basic visual processing and different levels of social cognition in a transdiagnostic youth sample.

methodsA sample of 148 youth, ranging from healthy individuals to individuals with neuropsychiatric diagnoses and significant social dysfunction, completed two measures of basic visual processing (contrast sensitivity and visual integration) and a battery of social cognition tasks spanning lower-level (gaze perception) to mid-level (emotion recognition) to higher-level (theory of mind) social cognition. We used a four-level path model to test whether basic visual processing predicts gaze perception, which in turn predicts emotion recognition, which predicts theory of mind.

resultsPoorer contrast sensitivity and visual integration were associated with less precise gaze perception, which was, in turn, associated with worse emotion recognition, which was associated with worse theory of mind. This four-level path model demonstrated good fit and showed superior fit compared to alternative models.

conclusionsThese findings suggest that basic visual processing influences the perception of basic social cues (e.g. gaze direction), which subsequently impairs more complex social perception and inference. Notably, this study extends prior observations from individuals with chronic schizophrenia to a transdiagnostic youth sample, indicating that altered basic visual processing may be a shared mechanism contributing to social cognitive deficits across psychiatric disorders and illness stages.

Indexed as

Facial RecognitionFixation, OcularSocial CognitionSocial PerceptionTheory of MindVisual PerceptionAdolescentContrast SensitivityEmotionsFemaleHumansMaleYoung Adultcontrast sensitivityemotion recognitiongaze perceptionsocial cognitiontheory of mindtransdiagnosticvisionvisual integration

Identifiers

PMID42132002
PMCPMC13200143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.