Evidence map›Paper›PMID 42131919›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2026

Prelamin A in an

Yuexia Wang, Leroy C Joseph, Cecilia Östlund, George Kuriakose, Wei Hsu, Susan Michaelis, Howard J Worman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yuexia WangDepartment of Medicine (Y.W., L.C.J., C.Ö., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0001-5461-7469
Leroy C JosephDepartment of Medicine (Y.W., L.C.J., C.Ö., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, New York.
Cecilia ÖstlundDepartment of Medicine (Y.W., L.C.J., C.Ö., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, New York.
George KuriakoseDepartment of Medicine (Y.W., L.C.J., C.Ö., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, New York.
Wei HsuDepartment of Craniofacial Biology and Bioengineering, The ADA Forsyth Institute, Somerville, MA (W.H.).ORCID 0000-0001-6738-6030
Susan MichaelisDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD (S.M.).ORCID 0000-0001-5851-5021
Howard J WormanDepartment of Medicine (Y.W., L.C.J., C.Ö., G.K., H.J.W.), Vagelos College of Physicians and Surgeons, Columbia University, New York.ORCID 0000-0002-7063-7889

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Role for prelamin A in premature and physiological agingR01AG075047 · NIA · JOHNS HOPKINS UNIVERSITY · PI Susan D. Michaelis, Howard J Worman · 2022 to 2026
$3.0M
NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696NIA NIH HHS R01 AG075047
6 · The paper itself

Abstract

backgroundHutchinson-Gilford progeria syndrome is an accelerated aging disorder characterized by numerous symptoms, including early onset atherosclerosis, myocardial infarctions, and strokes. Hutchinson-Gilford progeria syndrome is caused by mutations in

methodsTo assess the effects of prelamin A expression on atherosclerosis and aortic media vascular smooth muscle cells, we used

resultsAtherosclerotic plaque lesion area and necrotic core area were not different in hyperlipidemic

conclusionsIn contrast to the prelamin A variant progerin expressed in Hutchinson-Gilford progeria syndrome, prelamin A does not appear to cause vascular smooth muscle loss, promote atherosclerosis, or drive vascular aging in

Indexed as

Aortic DiseasesAtherosclerosisLamin Type AMuscle, Smooth, VascularMyocytes, Smooth MuscleProgeriaProtein PrecursorsAnimalsAortaApoptosisCell ProliferationCells, CulturedDisease Models, AnimalMaleMiceMice, Inbred C57BLLamin Type ALmna protein, mouseprelamin AProtein PrecursorsReceptors, LDLapoptosisatherosclerosishyperlipidemiaslaminsmyocardial infarctionpoint mutationprogeria

Identifiers

PMID42131919
PMCPMC13211879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.