ArticleDiagnostic cytopathology2026
Basaloid Squamous Cell Carcinoma of the Uterine Cervix: An Often Aggressive Subtype Frequently Underestimated by Cytology.
Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Basaloid squamous cell carcinoma of the cervix (BSCC) is an extremely rare subtype. In the 2020 WHO classification, BSCC is considered a subtype within HPV-associated squamous cell carcinoma. We report a case wherein liquid-based cytology (LBC) initially suggested a high-grade squamous intraepithelial lesion (HSIL). Retrospective review, prompted by the histologic diagnosis of BSCC, revealed diffuse sheets of monotonous basaloid and parabasaloid cells. Key cytologic features included three-dimensional clusters with occasional papillary architecture, palisading, and cord-like arrangements-findings that can be misleading. This case underscored that BSCC's deceptively bland cytology often overlaps with HSIL, contributing to diagnostic under-call. Increased awareness of these subtle yet distinctive patterns is crucial for accurate identification and appropriate clinical management of this rare variant.
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