Evidence map›Paper›PMID 42131875›Full record

ArticleTetrahedron letters2025

Advances in Vicinal Dicarbo-C-H-functionalization of Five-Membered Heteroarenes via Palladium/Norbornene Cooperative Catalysis.

Yun Zhou, Renhe Li, Rong Ye, Qi Zhu, Xin Liu, Guangbin Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun ZhouDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.
Renhe LiDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.
Rong YeDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.
Qi ZhuDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.
Xin LiuDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.
Guangbin DongDepartment of Chemistry, University of Chicago, 5735 S Ellis Ave, Chicago, IL 60637, USA.

Funding

New Directions in Palladium/Norbornene Cooperative-RenewalR01GM124414 · NIGMS · UNIVERSITY OF CHICAGO · PI DONG, GUANGBIN · 2018 to 2025
$2.6M
NIGMS NIH HHS R01 GM124414
6 · The paper itself

Abstract

Direct introduction of two carbon substituents to less functionalized aromatic cores has been an attractive objective for late-stage modification and streamlined synthesis of complex molecules. Using the palladium/norbornene (Pd/NBE) cooperative catalysis, while initial achievements on double C-H functionalization were made in the past, the scopes of reactions and substrates remain to be expanded. Here we report some new advances on the Pd/NBE-catalyzed dicarbofunctionalization of five-membered heteroarenes through sequential C-H activation. These efforts include the Pd/NBE-catalyzed C4-arylation/C5-alkenylation of diverse furans, the first C4-alkynylation of thiophenes/pyrroles, and the preliminary C4-methylation.

Indexed as

C–H activationC–H alkynylationdicarbofunctionalizationheteroarenespalladium/norbornene catalysis

Identifiers

PMID42131875
PMCPMC13166165

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.